EFFECTS OF SMOOTH MUSCLE RELAXANT (ASPAMINOL) ON Ca-UPTAKE BY MITOCHONDRIAL AND MICROSOMAL FRACTIONS FROM RAT UTERUS
スポンサーリンク
概要
- 論文の詳細を見る
A smooth muscle relaxant, Aspaminol (1,1-diphenyl-3-piperidinobutanol hydrochloride) relaxed a KCl-depolarized rat uterus and shifted a dose response curve of CaCl_2 towards higher doses. Aspaminol, a tertiary amine, may penetrate into the KCl-depolarized muscle cells. In order to study mechanisms for relaxation of the KCl-depolarized rat uterus by Aspaminol, effects of Aspaminol on Ca-uptake by mitochondrial and microsomal fractions from the rat uterus were studied. Aspaminol inhibited Ca-uptake by both fractions. Inhibition of Ca-uptake by the mitochondrial fraction seems to increase intracellular Ca^<2+>. Therefore, inhibition of Ca-uptake by the mitochondrial fraction is considered to be not associated with relaxation of uterus induced by Aspaminol. Since the microsomal fraction is known to form microsacs, the microsomal fraction was used as smooth muscle models. Inhibitory effect of Aspaminol on Ca-uptake by the microsomal fraction suggest a decrease in the intracellular concentration of Ca^<2+> of the uterine smooth muscle relaxed under the influence of Aspaminol.
- 公益社団法人日本薬学会の論文
著者
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Koike Katsuo
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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HISAYAMA Tetsuhiro
Department of Pharmacology, Faculty of Pharmaceutical Scienses, The University of Tokushima
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Takayanagi Issei
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Hisayama Tetsuhiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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HISAYAMA Tetsuhiro
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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