Effect of aging on the response of guinea pig trachea to isoprenaline.
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概要
- 論文の詳細を見る
To study the effect of aging on the β-adrenergic receptor potency of isoprenaline, tracheas from 3-, 6-, 10-, 40 and 100-week-old guinea pigs were used as test tissues. The pD<SUB>2</SUB> values (potency) of isoprenaline increased with age in tracheas treated with corticosterone, but decreased in untreated tracheas. The pA<SUB>2</SUB> value of propranolol against isoprenaline estimated in the treated tracheas did not change with age. Specific binding of [<SUP>3</SUP>H]-dihydroalprenolol to the microsomal fractions from the tracheal muscles from 6-, 10- and 40-week-old guinea pigs was analyzed with Scatchard plots. The capacity of maximum binding sites of [<SUP>3</SUP>H]-dihydroalprenolol increased with increasing age, while its dissociation constant did not change. Age-related increase in the potency of isoprenaline in the tracheas treated with corticosterone is considered to be due to the increase in the total amount (density) of β-adrenoceptors. However, the potency of the drug in untreated tracheas decreased with age. These results suggest that extraneuronal uptake plays an important role in the β-adrenergic action of isoprenaline in older (40 and 100 weeks) guinea pigs.
- 公益社団法人 日本薬理学会の論文
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Kawano Ken-ichi
Department Of Orthopaedic Surgery Graduate School Of Medicine University Of Tokyo
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