β-Adrenoceptors in the Detrusor of Guinea Pig Bladder
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概要
- 論文の詳細を見る
In the present study, we tried to determine which β-adrenoceptor subtypes are involved in the inhibitory regulation of bladder motility in the guinea pig by using in vitro functional analysis. Isoprenaline, norepinephrine and epinephrine decreased spontaneous contractile activity of the bladder concentration-dependently, the rank order of their potency being isoprenaline (pD_2=7.38) > norepinephrine (6.71) > epinephrine (6.31). Dobutamine was also effective in inhibiting the spontaneous contraction (5.81). However, CGP-12177, BRL37344, salbutamol, and clenbuterol were not effective at the concentration of 30 μM. The concentration-response curves of catecholamines (isoprenaline, norepinephrine and epinephrine) were rightward shifted by the presence of atenolol. Schild regression analyses carried out for atenolol against isoprenaline, norepinephrine and epinephrine gave pA_2 values of 6.93, 6.78 and 6.69, respectively. The concentration-response curve for isoprenaline was unaffected by 10 μM butoxamine. In the presence of 1 μM propranolol, bupranolol produced shifts of the concentration-response curve for isoprenaline, and the apparent pA_2 value for bupranolol against isoprenaline was 5.50. These results suggest that the inhibition of spontaneous contraction of the guinea pig bladder by β-adrenoceptor agonists is mediated mainly via β_1-adrenoceptor and the effect of isoprenaline is mediated partly via atypical β-adrenoceptor subtype.
- 日本平滑筋学会の論文
著者
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Koike Katsuo
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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YAMAMOTO Yoshihisa
Department of Physics, Tokyo Institute of Technology
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MORI Akari
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Mori Akari
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Yamamoto Yoshihisa
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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