Adrenaline produces the relaxation of guinea-pig airway smooth muscle primarily through the mediation of β_2-adrenoceptors
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概要
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The β-adrenoceptor subtype that mediates adrenaline-induced relaxation was pharmacologically identified in smooth muscle cells of the isolated guinea-pig trachea. Adrenaline produced a concentration-dependent relaxation with a pD_2 value of 7.1. The concentration-response curve for adrenaline was shifted rightwards in a competitive fashion by the β_1-/β_2-nonselective antagonists propranolol and bupranolol, with pA_2 values of 8.85 and 8.97, respectively. Adrenaline-induced relaxation was not affected by the β_1-selective antagonists atenolol and CGP-20,712A within the concentration ranges supposed to antagonize the β_1-subtype (atenolol, ≤10^<-6> M; CGP-20,712A, ≤10^<-8> M). By contrast, the concentration-response curve for adrenaline was shifted rightwards in a competitive fashion by atenolol at concentrations ≤3×10^<-6> M with a pA_2 value of 5.77. The concentration-response curve for adrenaline was also competitively antagonized by the β_2-selective antagonists butoxamine and ICI-118,551 with pA_2 values of 6.86 and 8.73, respectively. The pA_2 values of β-adrenoceptor antagonists (propranolol, bupranolol, atenolol, butoxamine and ICI-118,551) tested against adrenaline were consistent with the values when tested against salbutamol, a β_2-selective adrenoceptor agonist. The present findings provide evidence that the relaxant response of the smooth muscle of the guineapig trachea to the adrenal medulla hormone, adrenaline, is mainly mediated through β_2-adrenoceptors.
- 日本平滑筋学会の論文
著者
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KOIKE Katsuo
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Koike Katsuo
東京薬科大学 内分泌分子薬理学
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Koike K
Toho Univ. School Of Pharmaceutical Sci. Chiba Jpn
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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KOIKE Katsuo
Toho University School of Pharmaceutical Sciences
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Koike K
Toho Univ. Chiba Jpn
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Tanaka Yoshio
Dep. Of Chemical Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Toyoda Yoshihiro
Sagami Research Laboratory Wakamoto Pharmaceutical Co. Ltd.
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Horinouchi Takahiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Horinouchi T
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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YAMASHITA Yoko
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Yamashita Yoko
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Yamashita Yoko
Department Of Biotechnology Kyoto Sangyo University
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Yoshio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Horinouchi Takahiro
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Horinouchi Takahiro
Department Of Cellular Pharmacology Graduate School Of Medicine Hokkaido University
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