PLATELET ACTIVATING FACTOR ANALOGUES : LACK OF CORRELATION BETWEEN THEIR ACTIVITIES TO PRODUCE HYPOTENSION AND ENDOTHELIUM-MEDIATED VASODILATION
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概要
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Hypotensive activities of 11 synthetic derivatives of platelet activating factor (PAF) were examined and compared with their activities to produce endothelium-related relaxation of isolated rat thoracic aorta. The derivatives showed variety of hypotensive activities ; some of the derivatives were more potent than natural PAF and some were virtually inactive compared to PAF. However, all of the compounds tested exhibited exactly the same activities to produce endothelium-related vasodilation. These results confirmed our previous view that the PAF-induced hypotension is not solely due to the endothelium-related vascular relaxation observed in vitro.
- 公益社団法人日本薬学会の論文
著者
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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MASUDA YUKINORI
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Masuda Yukinori
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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KASUYA TUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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Tanaka Yoshio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Tanaka Yoshio
Department Of Applied Chemistry Faculty Of Engineering Yokohama National University
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Kasuya Tutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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