Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium
スポンサーリンク
概要
- 論文の詳細を見る
The effects of K+-channel blockers on the action potential duration of the myocardium were examined in isolated right ventricles from the 7 – 10-day-old, 11 – 13-day-old, and 14 – 20-day-old embryo and 1 – 7-day-old hatched chicks. E-4031 significantly prolonged action potential duration at all developmental stages examined; the prolongation was largest in the 11 – 13-day-old embryo and was accompanied by early after-depolarizations. Chromanol 293B showed smaller prolongation at all stages examined. Terfenadine prolonged action potential duration in the 11 – 13-day-old embryo, but not in other stages. Thus, the chick ventricular myocardium changes its repolarization properties during development.
著者
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Nouchi Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kiryu Naoaki
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Kimata Mikio
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Hamaguchi Shogo
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Tsuneoka Yayoi
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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Kimata Mikio
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Hamaguchi Shogo
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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