Famotidine neither affects action potential parameters nor inhibits human ether-a-go-go-related gene (hERG) K^+ current
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概要
- 論文の詳細を見る
The direct effects of famotidine, a selective histamine H_2 receptor antagonist, on the cardiac repolarization process were assessed using two in vitro test systems. Neither famotidine (0.1 and 1μM), nor its solvent, dimethylsulfoxide (0.1%), affected any of the action potential parameters of guinea-pig papillary muscles, whereas the positive control, dl-sotalol (30μM), significantly prolonged the action potential duration. Moreover, neither famotidine (0.1, 1 and 10μM) nor dimethylsulfoxide affected the human ether-a-go-go-related gene (hERG) K^+ current expressed in Chinese hamster ovary-K1 cells, whereas the positive control, E-4031 (0.1μM), significantly decreased the current. These results indicate famotidine does not directly affect the cardiac repolarization process.
- 日本トキシコロジー学会の論文
- 2009-10-01
著者
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department of Pharmacology, School of Medicine, Toho University, Japan
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Nakamura Yuji
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Sugiyama A
Department Of Pharmacology Yamanashi Medical University
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Nakamura Yuji
Department Of Materials Engineering Graduate School Of Engineering The University Of Tokyo:crest Jap
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical College
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Nakamura Yuji
Department Of Agricultural Chemistry Faculty Of Agriculture Kyushu University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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Takahara Akira
Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Toho University
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