Electrophysiological and Pharmacological Characteristics of Triggered Activity Elicited in Guinea-Pig Pulmonary Vein Myocardium
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概要
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The pulmonary vein is known as an important source of ectopic beats, initiating frequent paroxysms of atrial fibrillation. We analyzed electrophysiological and pharmacological characteristics of triggered activity elicited in the isolated pulmonary vein from the guinea pig. Immediately after the termination of train stimulation (pacing cycle length of 100 ms), spontaneous activities accompanied with phase-4 depolarization were detected in 43 out of 45 pulmonary vein preparations. Such triggered activities were not observed in the isolated left atrium. The incidence of triggered activity was higher at a shorter pacing cycle length (100 – 200 ms), and the coupling interval was shorter at a shorter pacing cycle length. Verapamil (1 μM), ryanodine (0.1 μM), and pilsicainide (10 μM) suppressed the occurrence of triggered activities. The resting membrane potential of the pulmonary vein myocardium was more positive than that of the left atrium. Carbachol (0.3 μM) hyperpolarized the resting membrane potential and completely inhibited the occurrence of triggered activities. These results suggest that the pulmonary veins have more arrhythmogenic features than the left atrium, possibly through lower resting membrane potential. The electrophysiological and pharmacological characteristics of triggered activity elicited in the pulmonary vein myocardium were similar to those previously reported using ventricular tissues.
著者
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tsuneoka Yayoi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Takahara Akira
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Sugimoto Takahiko
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Kitamura Takuma
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Takeda Kiyoshi
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences, Japan
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Suzuki Takuo
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Takahara Akira
Department Of Internal Medicine National Kawatana Hospital
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Takeda Kiyoshi
Department Of Microbiology And Immunology Graduate School Of Medicine Osaka University
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Takeda Kiyoshi
Department Of Anesthesia Osaka National Hospital
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Tsuneoka Yayoi
Department Of Molecular Biotechnology Graduate School Of Advanced Science Of Matter Hiroshima Univer
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Kitamura Takuma
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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