Effect of Manganese on Guinea Pig Ventricle : Initial Depression and Late Augmentation of Contractile Force
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概要
- 論文の詳細を見る
Effects of Mn^<2+> on isolated guinea pig ventricular myocardia were examined. In isolated papillary muscles, Mn^<2+> produced a transient decrease in contractile force followed by a late sustained augmentation. Mn^<2+> markedly increased the amplitude of post-rest contractions ; the time course of potentiation was almost the same as that of the late augmentation of contractile force after Mn^<2+> application. Mn^<2+> also increased the amplitude of rapid-cooling contractures. The negative inotropic effect of diltiazem and nicardipine was not affected by the presence of Mn^<2+>. Mn^<2+> shortened the action potential duration under normal condition whereas it prolonged the duration under Ca^<2+> free conditions. Mn^<2+>, when applied to fura-2-loaded ventricular myocytes, markedly quenched the cytoplasmic fluorescence excited at 360nm wavelength. We concluded that Mn^<2+> not only causes a decrease in contractile force by blocking the L-type Ca^<2+> channel, but also enters the cytoplasm through the channel and produces late augmentation of the contractile force through enhancement of sarcoplasmic reticulum function.
- 公益社団法人日本薬学会の論文
- 2002-03-01
著者
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MIYAMOTO Yusuke
Department of Electrical Engineering, Tokai University
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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ISHII Tadashi
Department of Anatomy, Tohoku University School of Medicine
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kawanishi Toru
国立医薬品食品衛生研究所
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FUJISAKI Ryoichi
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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TANAKA Yoshino
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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AIKAWA Tokiko
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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HIRAYAMA Wataru
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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Aikawa Tokiko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Yoshino
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Miyamoto Y
Department Of Electrical Engineering Tokai University
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Hirayama Wataru
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Miyamoto Y
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Fujisaki Ryoichi
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Miyamoto Yusuke
Department Of Electrical Engineering Tokai University
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Ishii Tadashi
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Aikawa Tokiko
Department Of Pharmacology And Therapeutics Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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