The R(-)-Enantiomer of Efonidipine Blocks T-type but Not L-type Calcium Current in Guinea Pig Ventricular Myocardium
スポンサーリンク
概要
- 論文の詳細を見る
In guinea pig ventricular cardiomyocytes, the R(−)-enantiomer of efonidipine concentration-dependently blocked T-type Ca2+ current with 85% inhibition at 1 μM. In contrast, R(−)-efonidipine (1 μM) had no effect on the L-type Ca2+ current and Ca2+ transient in cardiomyocytes and contractile force in papillary muscles. Thus, R(−)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardia.
- 社団法人 日本薬理学会の論文
- 2004-12-01
著者
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Shimada Hideaki
Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu Universi
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Shimada Hideaki
千葉大学 医学研究院先端応用外科学
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Shimada H
Department Of Frontier Surgery Graduate School Of Medicine Chiba University
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Takeda Kentaro
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Shiina Hiroyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimada Hideaki
Department Of Gastroenterological Surgery Chiba Cancer Center
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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KOMIKADO Chisa
Department of Pharmacology, Toho University Faculty of Pharmaceutical Sciences
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Komikado Chisa
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimada H
Kumamoto Univ. Kumamoto
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Shimada Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Science
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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Shimada Hideaki
Department Of Frontier Surgery Chiba University Graduate School Of Medicine
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Shimada Hideaki
Department Of Academic Surgery Graduate School Of Medicine Chiba University
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Sakurai Haruna
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Sashiyama Hiroshi
千葉大学 医学研究院先端応用外科学
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Shimada Hideaki
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Takeda Kiyoshi
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Takeda Kentaro
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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