Mobilization of Renal and Hepatic Cadmium by Dithiocarbamates in Rats
スポンサーリンク
概要
- 論文の詳細を見る
Sodium N-benzyl-D-glucamine dithiocarbamate (BGD), sodium N-p-hydroxymethylbenzyl-D-glucamine dithiocarbamate (HBGD), sodium N-p-carboxybenzyl-D-glucamine dithiocarbamate (CBGD), and sodium N-p-methoxybenzyl-D-glucamine dithiocarbamate (MeOBGD) were evaluated for their efficacy in the distribution and excretion of cadmium in rats exposed to cadmium. Rats were injected intraperitoneally with ^<109>CdCl_2 (1 mg Cd/kg and 74 kBq of ^<109>Cd/one animal) and 30 min or 24 h later, they were injected with chelating agents all significantly enhanced the biliary excretion of cadmium. At 24 h after cadmium injection, BGD and MeOBGD were the most effective on the biliary excretion of the metal. These chelating agents were effective in mobilizing cadmium from the liver at 30 min after cadmium treatment. At 24 h after cadmium treatment, BGD and MeOBGD significantly depressed cadmium content in the liver. In another experiment, rats were injected intraperitoneally with ^<109>CdCl_2 and 3 d later, they were injected with BGD, HBGD, or MeOBGD every other day for 2 weeks. The fecal excretion of cadmium was significantly increased by these chelating agents and MeOBGD was the most effective. The hepatic and renal cadmium contents were significantly decreased after BGD, HBGD or MeOBGD injection. The injection of MeOBGD to rats pretreated with cadmium was more effective than that of BGD, HBGD, or CBGD in removing cadmium from the liver. HBGD injection was more effective in decreasing the cadmium content in the kidney. The treatment with these chelating agents did not cause the redistribution of cadmium to brain, testes, and heart.
- 公益社団法人日本薬学会の論文
著者
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島田 秀昭
熊本大学教育学部
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Shimada Hideaki
Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu Universi
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Shimada Hideaki
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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KOJIMA Shoji
Laboratory of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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KAMENOSONO Takeshi
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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KAWAGOE Minoru
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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FUNAKOSHI Takayuki
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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KIYOZUMI Morio
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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TAKADATE Akira
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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KOJIMA Shoji
Department of Hygienic Chemistry, Faculty of Pharmaceutical Sciences, Kumamoto University
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KAWAGOE MINORU
Faculty of Pharmaceutical Sciences, Kumamoto University
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Kawagoe M
Faculty Of Pharmaceutical Sciences Kumamoto University
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船越 崇行
Kyushu University of Nursing and Social Welfare
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Kamenosono Takeshi
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Shimada Hideaki
Department Of Academic Surgery Graduate School Of Medicine Chiba University
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島田 秀昭
熊本大 薬
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Kojima S
Laboratory Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University
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Kojima Shoji
Department Of Applied Physics Faculty Of Science Tokyo University Of Education
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Kiyozumi Morio
Faculty Of Education Kumamoto University
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Kojima Shoji
Faculty Of Pharmaceutical Sciences Kumamoto University
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Takadate Akira
Department Of Hygienic Chemistry Faculty Of Pharmaceutical Sciences Kumamoto University:department O
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Shimada Hideaki
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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Kojima Shoji
Department Of Applied Physics Faculity Of Science Tokyo University Of Education
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