Increase of Calcium Concentration in the Testes of Mice Treated with Rare Earth Metals
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概要
- 論文の詳細を見る
Rare earth metals (REMs) are widely used in several emerging technologies, however, little is known about their biological effects. In this study we examined the effects of REMs, including lanthanum (La), neodymium (Nd), gadolinium (Gd), terbium (Tb) and ytterbium (Yb) on the testes of mice. Mice were treated i.v. with a single dose of 20 or 200μmol REM/kg as chloride. The testicular weights, lipid peroxidation, and alterations such as hemorrhagic inflammation, were examined 5 d after the administration. The concentration of Ca in the testes was also determined by atomic absorption spectrometer. No significant changes in testicular weights, lipid peroxidation, or alterations were observed by the administration of these REMs at either dose. However, the concentration of Ca in the testes was markedly increased at both doses. There was no significant difference in the Ca concentration between dose levels or among the REMs. These results suggest that the REMs induce increased Ca concentration in mice testes, and this might be a significant aspect of their toxic mechanisms.
- 公益社団法人日本薬学会の論文
- 2000-08-01
著者
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島田 秀昭
熊本大学教育学部
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Shimada Hideaki
Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu Universi
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YASUTAKE Akira
National Institute for Minamata Disease
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Yasutake A
National Inst. For Minamata Disease Kumamoto Jpn
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Yasutake Akira
Biochemistry Section National Inst. For Minamata Disease
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Yasutake Akira
Biochemistry Section Department Of Basic Medical Sciences National Institute For Minamata Disease
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Yasutake Akira
National Inst. For Minamata Disease
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Nagano Masaaki
Biochemistry Section National Inst. For Minamata Disease
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Nagano Masaaki
National Institute For Minamata Disease
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Nagano Masaaki
Department Of Basic Medical Sciences National Institute For Minamata Disease
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船越 崇行
Kyushu University of Nursing and Social Welfare
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Funakoshi Takayuki
Kyushu University of Nursing and Social Welfare
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Shimada Hideaki
Department Of Academic Surgery Graduate School Of Medicine Chiba University
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島田 秀昭
熊本大 薬
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Shimada Hideaki
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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