Effect of Magnesium Sulfate on the Haloperidol-Induced QT Prolongation Assessed in the Canine In Vivo Model Under the Monitoring of Monophasic Action Potential
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概要
- 論文の詳細を見る
Haloperidol has been reported to induce polymorphic ventricular arrhythmias associated with QT prolongation. The present study examined the effects of magnesim sulfate on the cardiovascular system suffering from haloperidol overdose. Beagle dogs were anesthetized with halothane inhalation under the monitoring of monophasic action potential (n=6). After intravenous administration of an intentionally high dose of haloperidol (3mg/kg), the heat rate (HR), left ventricular contraction and mean blood pressure (BP) decreased, and the ventricular repolarization phase and effective refractory period (ERP) were prolonged, the increment in the former being than in the latter, indicating an increase in electrical vulnerability. However, preload of the left ventricle, cardiac output (CO) and cardiac conduction were hardly affected. An additional intravenous dose of 100mg/kg of magnesium sulfate increased the preload of the left ventricle, and decreased the HR, mean BP, left ventricular contraction and CO, suppressed atrioventricular as well as intraventricular conduction, and prolonged the ventricular repolarization phase and ERP, in which the increment of the repolarization phase was similar to that of ERP. These results suggest that magnesium sulfate hardly affects the electrical vulnerability of the heart during haloperidol overdose, but may block the calcium, potassium and sodium channels, which may explain its antiarrhythmic action.
- 社団法人日本循環器学会の論文
- 2000-05-20
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Sugiyama Atsushi
Department of Pharmacology, School of Medicine, Toho University, Japan
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Satoh Y
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Tamura Kohji
Second department of Medicine, Yamanashi Medical School
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TAMURA Kohji
2nd Department of Internal Medicine, Yamanashi Medical College
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Tamura Kohji
The Second Department of Internal Medicine, Yamanashi Medical University
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Tamura Kohji
1st. Department Of Med. Niigata University
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Tamura K
The Second Department Of Internal Medicine Yamanashi Medical University
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Tamura Kohji
The 1st. Depertment Of Internal Medicine Niigata University School Of Medicine.
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Tamura Kohji
Second Department Of Internal Medicine Yamanashi Medical College
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Tamura Kohji
1st. Dept. Of Internal Medicine Niigata University School Of Medicine
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SATOH Yoshioki
Second Department of Internal Medicine , Yamanashi Medical University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Tamura Kohji
The First Department Of Medicine Anatomy And Thoracic And Vascular Surgery Niigata University School
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Tamura Kohji
2nd Dept Of Medicine Yamanashi Medical University
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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TAMURA Kohji
Department of Medicine, Yamanashi Medical College
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TAMURA Kohji
Second Department of Internal Medicine, Yamanashi Medical College
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