Slowing Na^+ Channel Inactivation Prolongs QT Interval and Aggravates Adrenaline-Induced Arrhythmias
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概要
- 論文の詳細を見る
We investigated the effects of prolonged repolarization induced by slowed inactivation of Na+ channel on adrenaline-induced arrhythmias in halothane anesthetized, closed-chest dogs. We used sea anemone toxins (ATX-II and Anthopleurin-A) to prolong ventricular repolarization and examined their effects on adrenaline arrhythmias. Sea anemone toxins prolonged the QTc- and JTc-intervals (P<0.01), but did not affect the PQ interval, QRS duration, heart rate and mean blood pressure. Although sea anemone toxins did not induce any arrhythmias by themselves, under the treatment with these toxins, arrhythmias were induced by non-arrhythmia-inducing doses of adrenaline in four dogs out of seven and the control arrhythmias induced by adrenaline were aggravated. These results indicate that, similar to the inhibition of K+ channels by class III drugs, which we have already reported, slowing Na+ channel inactivation with QTc prolongation also aggravates adrenaline-induced arrhythmias.
- 社団法人 日本薬理学会の論文
- 2001-05-01
著者
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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AYE Nu
Department of Pharmacology, Yamanashi Medical University
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MIYAMOTO Shigeki
Department of Pharmacology, Yamanashi Medical University
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Matsumaga Sigeki
Department Of Aquatic Bioscience Graduate School Of Agricultural And Life Sciences University Of Tok
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Miyamoto Shigeki
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Aye Nu
Department Of Pharmacology Yamanashi Medical University
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Zhu Bing-mei
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Miyamoto S
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Zhu Bing-Mei
Department of Pharmacology and Department of Human Science, Yamanashi Medical University
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HASHIMOTO Keitaro
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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