THE EFFECT OF PRETREATMENT WITH MORICIZINE ON EARLY ARRHYTHMIA RESULTING FROM MYOCARDIAL ISCHEMIA IN RATS
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概要
- 論文の詳細を見る
Moricizine (moracizine) is a new class I antiarrythmic drug which is undergoing a large scale clinical trial at present. A rat model was used to compare the effects of moricizine (5 mg/kg i.v), disopyramide (DSP 5 mg/kg i.v) and mexiletine (MXT 5 mg/kg i,v) on early ventricular arrhythmias occurring within 30 min after ligation of the left coronary artery. After intravenous administration, all three drugs slowed the heart rate significantly (p<0.01), and compared to the control group only moricizine significantly increased the systolic, diastolic and mean arterial blood pressures. The total number of premature ventricular complexes were as follows; control group (n=9); 1666±250 beats, moricizine group (n=7); 1645±417 beats (NS), DSP group (n=10); 325±155 beats (p<0.01 vs control) and MXT group (n= 10); 733±147 beats (p<0.01 vs control). The incidence of primary ventricular fibrillation, was significantly reduced by DSP and MXT (10% reduction and 20% reduction respectively) (p<(0.05), while morici-zine (incidence 80%) had no effect in comparison to the control group (incidence 90%). Death due to arrhythmia was completely abolished by DSP and MXT; although moricizine showed a slight tendency to increase the mortality rate, but the difference was not significant. In conclusion, moricizine has no obvious protective effect on early ventricular arrhythmias resulting from coronary artery occlusion in rats.
- 社団法人日本循環器学会の論文
- 1992-03-20
著者
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Tamura Kohji
The Second Department Of Internal Medicine Yamanashi Medical College
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Komori Sadayoshi
The Second Department Of Internal Medicine Yamanashi Medical College
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He Zhu
The Second Department Of Internal Medicine Yamanashi Medical College
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Yamanashi Medical College
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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