THE ROLE OF OXYGEN FREE RADICALS AND EXTRACELLULAR CALCIUM IONS IN REPERFUSION-INDUCED ARRHYTHMIAS

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概要

• 論文の詳細を見る

• To examine the role of oxygen free radicals and extracellular calcium ions in reperfusion-induced ventricular arrhythmias, we evaluated the effects of hypoxic reperfusion. oxygen free radical scavengers, allopurinol and hypocalcemic reperfusion on reperfusion-induced ventricular arrhythmias. The hearts of male Sprague-Dawley rats were perfused in the working heart mode. Whole heart ischemia was induced for 15 min and then reperfused. Rats were divided into 5 groups: control group, scavenger group, allopurinol group. hypoxia group and hypocalcemia group. Scavenger, hypoxic and hypocalcemic perfusions were undertaken only during the period of perfusion. The incidence of reperfusion-induced ventricular fibrillation (Vf) was reduced in the scavenger group (100% to 38%) and the hypoxia group (100% to 50%). Spontaneous reversion of Vf to regular sinus rhythm was recognized in the hypoxia and hypocalcemia groups. In conclusion, oxygen free radicals would play an important role in the genesis of the reperfusion arrhythmias, and extracellular calcium concentration would also play an important role in sustaining the reperfusion arrhythimias. Notably, hypoxic reperfusion had protective effects on both processes.

• 社団法人日本循環器学会の論文
• 1991-06-20

著者

• TAMURA Kohji

  2nd Department of Internal Medicine, Yamanashi Medical College

• Komori Sadayoshi

  Department of Second Internal Medicine, Yamanashi Medical University

• Osada Mitsuru

  The Second Department of Internal Medicine, Yamanashi Medical University

• Tamura Kohji

  The Second Department of Internal Medicine, Yamanashi Medical University

• SATO Takeshi

  the School of Engineering, Nagoya University

• Tamura Kohji

  1st. Department Of Med. Niigata University

• Tamura K

  The Second Department Of Internal Medicine Yamanashi Medical University

• Tamura Kohji

  The 1st. Depertment Of Internal Medicine Niigata University School Of Medicine.

• Tamura Kohji

  The Second Department Of Internal Medicine Yamanashi Medical College

• Osada M

  Department Of Internal Medicine Ii Yamanashi University

• Okumura Mitsuru

  Department Of Medicine Aoto Hospital Jikei University School Of Medicine

• Komori Sadayoshi

  The Second Department Of Internal Medicine Yamanashi Medical College

• Komori Sadayoshi

  Second Department Of Internal Medicine Yamanashi Medical College

• Tamura Kohji

  Second Department Of Internal Medicine Yamanashi Medical College

• Osada Mituru

  Department Of Internal Medicine Ii Yamanashi University

• Tamura Kohji

  1st. Dept. Of Internal Medicine Niigata University School Of Medicine

• Takeda Satosi

  Department Of Inernal Medicine The Jikei University School Of Medicine Aoto Hospital

• Tamura Kohji

  The First Department Of Medicine Anatomy And Thoracic And Vascular Surgery Niigata University School

• Tamura Kohji

  2nd Dept Of Medicine Yamanashi Medical University

• TAMURA Kohji

  Department of Medicine, Yamanashi Medical College

• TAMURA Kohji

  Second Department of Internal Medicine, Yamanashi Medical College

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