THE PROTECTIVE EFFECT OF PRECONDITIONING ON REPERFUSION-INDUCED ARRHYTHMIA IS LOST BY TREATMENT WITH SUPEROXIDE DISMUTASE

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概要

• 論文の詳細を見る

• The purpose of this study was to investigate the relation between free radicals and the effect of preconditioning on reperfusion arrhythmias using the isolated working rat heart model. Rats were divided into 3 groups: control, preconditioned without superoxide dismutase (SOD) and preconditioned with SOD (n=8 each group). The incidence of reperfusion-induced ventricular fibrillation (Vf) in the preconditioned without SOD group was reduced from 100% to 13% (p<0.005 vs control). This protective effect of preconditioning was not observed in the SOD-treated group (incidence of Vf increased from 13% to 75%, p<0.025). The protective effect of preconditioning on reperfusion arrhythmias is related to the presence of oxygen free radicals which occur during the reperfusion period of the preconditioning phase.

• 社団法人日本循環器学会の論文
• 1994-03-20

著者

• TAMURA Kohji

  2nd Department of Internal Medicine, Yamanashi Medical College

• Komori Sadayoshi

  Department of Second Internal Medicine, Yamanashi Medical University

• Osada Mitsuru

  The Second Department of Internal Medicine, Yamanashi Medical University

• Tamura Kohji

  The Second Department of Internal Medicine, Yamanashi Medical University

• SATO Takeshi

  the School of Engineering, Nagoya University

• Tamura Kohji

  1st. Department Of Med. Niigata University

• Tamura K

  The Second Department Of Internal Medicine Yamanashi Medical University

• Tamura Kohji

  The 1st. Depertment Of Internal Medicine Niigata University School Of Medicine.

• Tamura Kohji

  The Second Department Of Internal Medicine Yamanashi Medical College

• Osada M

  Department Of Internal Medicine Ii Yamanashi University

• Okumura Mitsuru

  Department Of Medicine Aoto Hospital Jikei University School Of Medicine

• Komori Sadayoshi

  The Second Department Of Internal Medicine Yamanashi Medical College

• Komori Sadayoshi

  Second Department Of Internal Medicine Yamanashi Medical College

• Tamura Kohji

  Second Department Of Internal Medicine Yamanashi Medical College

• Osada Mituru

  Department Of Internal Medicine Ii Yamanashi University

• Tamura Kohji

  1st. Dept. Of Internal Medicine Niigata University School Of Medicine

• TAKEDA SATOSHI

  The Second Department of Internal Medicine, Yamanashi Medical College

• Takeda Satosi

  Department Of Inernal Medicine The Jikei University School Of Medicine Aoto Hospital

• Tamura Kohji

  The First Department Of Medicine Anatomy And Thoracic And Vascular Surgery Niigata University School

• Tamura Kohji

  2nd Dept Of Medicine Yamanashi Medical University

• TAMURA Kohji

  Department of Medicine, Yamanashi Medical College

• TAMURA Kohji

  Second Department of Internal Medicine, Yamanashi Medical College

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