Effects of NS-2, a New Class 1 Antiarrhythmic Agent, and AFD-19, Its Active Metabolite, on Ventricular Arrhythmias Induced by Coronary Artery Occlusion and Reperfusion in Anesthetized Rats: Comparison with Disopyramide and Mexiletine.
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概要
- 論文の詳細を見る
We studied the antiarrhythmic effects of NS-2 (4-diisobutylamino-1, 1-diphenyl-l-butanol maleate) and AFD-19 (active metabolite of NS-2) on early stage ventricular arrhythmias induced by coronary artery occlusion and reperfusion in anesthetized male rats. These effects were compared with those of disopyramide and mexiletine. Drugs were intravenously administered either before or after coronary occlusion. When administered 5 min before occlusion, 3 mg/kg of NS-2 and AFD-19 exhibited equivalent anti-arrhythmic activity to that of 5 mg/kg of disopyramide and mexiletine, as assessed by reductions in the number of premature ventricular complexes and in the incidences of ventricular tachycardia and ventricular fibrillation. In a dose of 5 mg/kg, the antiarrhythmic effects of NS-2 and AFD-19 were more pronounced. When administered 5 min after coronary artery occlusion, only NS-2 and AFD-19 (in doses of 5 mg/kg) had significant antiarrhythmic effects. None of the drugs influenced the severe ventricular arrhythmias induced by reperfusion when administered 1 min before reperfusion. In conclusion, NS-2 might be effective in reducing the severity of the life-threatening ventricular arrhythmias that occur during acute myocardial infarction.
- 公益社団法人 日本薬理学会の論文
著者
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SAWANOBORI Takao
the Second Department of Internal Medicine, Yamanashi Medical University
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Tamura Kohji
The Second Department Of Internal Medicine Yamanashi Medical College
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Komori Sadayoshi
The Second Department Of Internal Medicine Yamanashi Medical College
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KOMORI SADAYOSHI
The Second Department of Internal Medicine, Yamanashi Medical College
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Kane Kathleen
Department of Physiology and Pharmacology, Strathclyde University
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Parratt James
Department of Physiology and Pharmacology, Strathclyde University
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- Effects of NS-2, a New Class 1 Antiarrhythmic Agent, and AFD-19, Its Active Metabolite, on Ventricular Arrhythmias Induced by Coronary Artery Occlusion and Reperfusion in Anesthetized Rats: Comparison with Disopyramide and Mexiletine.