Pravastatin Inhibits Arrhythmias Induced by Coronary Artery Ischemia in Anesthetized Rats
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概要
- 論文の詳細を見る
We have reported that chronically administered pravastatin prevented coronary artery reperfusion-induced lethal ventricular fibrillation (VF) in anesthetized rats without lowering the serum cholesterol level. The present study was undertaken to evaluate whether pravastatin prevents ischemia-induced lethal VF, simultaneously examining myeloperoxidase (MPO) activity in ischemic myocardial tissues. Anesthetized rats were subjected to 30-min ischemia and 60-min reperfusion after chronic administration of pravastatin (0.02, 0.2, and 2 mg/kg), fluvastatin (2 and 4 mg/kg), or vehicle for 22 days, orally, once daily. ECG and blood pressure were continually recorded, and MPO was measured by a spectrophotometer. Pravastatin and fluvastatin significantly (P<0.05) decreased MPO activities, but only pravastatin decreased the incidence of ischemia-induced lethal VF. Both statins had no significant effects on body weight, blood pressure, heart rate, and QT interval as we reported earlier. Our results prove further that pravastatin has benefits to decrease cardiovascular mortality beyond its cholesterol-lowering effect. Pravastatin is more potent than fluvastatin in prevention of arrhythmias. A decrease in the neutrophil infiltration may be partly involved in the inhibitory effect of pravastatin on the ischemia-induced VF.
- 社団法人 日本薬理学会の論文
- 2007-03-20
著者
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Shen Hua
Department Of Biochemistry Interdisciplinary Graduate School Of Medicine And Engineering University
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Tsurugi Kunio
Department Of Biochemistry Interdisciplinary Graduate School Of Medicine And Engineering University
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Tsurugi Kunio
Department Of Biochemistry 2 University Of Yamanashi Faculty Of Medicine
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NAGASAWA Yoshinobu
Department of Pharmacology, Interdisciplinary Graduate School of Medicine and Engineering, Universit
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Chen Jianguang
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Mitsui Kazuhiro
Department Of Biochemistry Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Nagasawa Yoshinobu
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Nagasawa Yoshinobu
Department Of Human Science And Fundamentals Of Nursing
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Tsurugi Kunio
Department Of Biochemistry 2 Faculty Of Medicine University Of Yamanashi
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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