Utilization of Telemetry System to Assess the Cardiovascular Profile of AH-1058, a New Cardioselective Ca^<2+> Channel Blocker, in Conscious Dogs
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概要
- 論文の詳細を見る
Cardiovascular effects of a new Ca2+ channel blocker AH-1058, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-[(E)-3-(3-methoxy-2-nitro)phenyl-2-propenyl]piperidine hydrochloride, were assessed in conscious dogs using a new telemetry system. AH-1058 (0.03, 0.1 and 0.3 mg/kg, i.v.) reduced systolic blood pressure and the maximal upstroke velocity of the left ventricular pressure and increased the heart rate in a dose-dependent manner without affecting the diastolic blood pressure; each of these responses lasted for several hours. These results support the previous knowledge that AH-1058 is a long-lasting cardiodepressive drug. The telemetry system provided important information for predicting favorable clinical effects of AH-1058.
- 社団法人 日本薬理学会の論文
- 2001-03-01
著者
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DOHMOTO Hideki
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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YOSHIMOTO Ryota
Pharmaceutical Research Laboratories, Ajinomoto Co., Inc.
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Dohmoto Hideki
Pharmaceutical Research Laboratories Pharmaceuticals Company Ajinomoto Co. Inc.
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Takahara Akira
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Yoshimoto Ryota
Pharmaceutical Research Laboratories Pharmaceuticals Company Ajinomoto Co. Inc.
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Yoshimoto Ryota
Pharmaceutical Research Laboratories Ajinomoto Co. Inc.
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology. University Of Yamanashi Yamanashi Research Center Of Cliniacl Pharmacolo
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Aikawa Tokiko
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Sugiyama Atsushi
Department Of Pharmacology School Of Medicine Toho University
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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