Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome
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概要
- 論文の詳細を見る
Extents of the sparfloxacin (3 – 10 mg/kg, i.v.)-induced QT interval prolongation under normokalemic and hypokalemic conditions were assessed in halothane-anesthetized beagle dogs (n = 5). The hypokalemic condition was induced by an oral administration of furosemide (200 mg/kg per day) for 3 days, which decreased the serum potassium concentration from 3.65 ± 0.13 to 2.35 ± 0.13 mM (P<0.05). However, the decrease of potassium concentration by itself did not affect the extent of the sparfloxacin-induced QT interval prolongation. These results indicate that acute hypokalemia may not severely sensitize the in situ heart for drug-induced long QT syndrome as previously thought.
- 社団法人 日本薬理学会の論文
- 2006-01-20
著者
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Takasuna Kiyoshi
New Product Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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CHIBA Katsuyoshi
New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.
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WATANABE Kazuo
New Product Research Laboratories II, Daiichi Pharmaceutical Co., Ltd.
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Chiba Katsuyoshi
New Product Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
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Chiba Katsuyoshi
New Product Res. Laboratories Ii Daiichi Pharmaceutical Co. Ltd. Jpn
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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Watanabe Kazuo
New Product Research Laboratories Ii Daiichi Pharmaceutical Co. Ltd.
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HASHIMOTO Keitaro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department of Biotechnology, Faculty of Engineering, Kansai University
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