Chronotropic, Inotropic, Dromotropic and Coronary Vasodilator Effects of Bisaramil, a New Class I Antiarrhythmic Drug, Assessed Using Canine Isolated, Blood-Perfused Heart Preparations
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概要
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The cardiovascular effects of a new class I antiarrhythmic drug, bisaramil, were examined using canine isolated, blood-perfused heart preparations. Bisaramil exerted negative chronotropic, inotropic and dromotropic effects as well as coronary vasodilator action, which are qualitatively the same as those of classical class I drugs. The selectivity of bisaramil for the intraventricular conduction vs the other cardiac variables was compared with that of disopyramide and flecainide. Bisaramil was the most selective for intraventricular conduction, while it was the least selective for ventricular muscle contraction. We conclude that bisaramil may become a useful antiarrhythmic drug with less cardiac adverse effects.
- 社団法人 日本薬理学会の論文
著者
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HARUNO Akihiro
Department of Phamacology, Yamanashi Medical University
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Sugiyama Atsushi
Department Of Pharmacology Yamanashi Medical University
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Hashimoto Keitaro
Department Of Pharmacology Interdisciplinary Graduate School Of Medicine And Engineering University
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Sugiyama Atsushi
Department Of Chemistry College Of Science Rikkyo University
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