EFFECTS OF OXIMES, DIACETYLMONOXIME, PYRIDINE-2-ALDOXIME, AND PYRIDINE-2-ALDOXIME METHOCHLORIDE, ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF GUINEA PIG CARDIAC VENTRICULAR MUSCLES
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概要
- 論文の詳細を見る
Effects of 3 oximes, diacetylmonoxime (DAM), pyridine-2-aldoxime (PAM) and pyridine-2-aldoxime methochloride (2-PAM), on the normal electrical and mechanical activities and on the slow response action potentials were examined in the guinea pig ventricular muscles. DAM and long-term exposure to high concentrations of PAM produced decreases in contractile force, action potential duration and slow response action potentials, whereas 2-PAM and low concentrations of PAM tended to increase these parameters. Thus, these 3 oximes did not act uniformly on cardiac muscle. It was speculated that DAM and high concentrations of PAM may act as slow channel inhibitors, whereas 2-PAM and low concentrations of PAM may act as slow channel activators.
- 公益社団法人日本薬学会の論文
著者
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Atoda(nee Tatusno)
Department Of Biochemistry Meiji College Of Pharmacy
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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