Action Potential Shortening and Negative Inotropic Effects of a Novel Potassium Channel Opener, NIP-121, as Compared with Cromakalim in Guinea Pig Ventricular Myocardium.
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概要
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The potencies of NIP-121, a new potassium channel opener, to shorten action potential duration and to decrease the contractile force was examined using isolated guinea pig right ventricular free wall and papillary muscle preparations, respectively; and they were compared with those of cromakalim. NIP-121 was about 10 times more potent than cromakalim with respect to both effects. This potency ratio in cardiac muscle was about the same as that observed in rat aorta and portal vein. These cardiac effects of both agents were antagonized by glibenclamide.
- 公益社団法人 日本薬理学会の論文
著者
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Watanabe Masahiro
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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Kageyama Chiemi
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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