Low Incidence of Hemorrhagic Infarction Following Coronary Reperfusion with Nasaruplase in a Canine Model of Acute Myocardial Infarction. Comparison with Recombinant t-PA.:Comparison with Recombinant t-PA
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概要
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An examination was made of the coronary thrombolytic effects of nasaruplase in a canine model of acute myocardial infarction. The model was produced by selective injection of an artificial thrombus into the coronary artery stenosed by laser ablation. Intravenous nasaruplase (8U/kg/min) showed an equivalent thrombolytic effect to a recombinant tissue-type plasminogen activator (rt-PA, 10, 000IU/kg/min) as assessed by reperfusion rate (78.6 versus 79.2%) and reperfusion time (37.4±5.2 versus 37.0±2.5min). Nasaruplase decreased the plasma α2-plasmin inhibitor (α2-PI) level by 28% immediately after reperfusion, but hardly altered fibrinogen or plasmin-α2-plasmin inhibitor complex (PIC) levels. By contrast, rt-PA significantly decreased plasma α2-PI and fibrinogen levels, by 84% and 92% respectively, and, increased PIC level more than 70-fold. Hemorrhagic infarction occurred in 2 of 14 animals in the nasaruplase group and in 9 of 19 animals in the rt-PA group. In these animals, significant correlations were found between the ratio of the hemorrhagic infarction area to total infarct area and the plasma α2-PI (r=-0.740, p<0.05) or fibrinogen (r=-0.798, p<0.05) concentrations, as well as between the recovery rate of left ventricular regional wall motion and the plasma α2-PI (r=0.924, p<0.01) or fibrinogen (r=0.864, p<0.01) concentrations. It is concluded that nasaruplase is a potent thrombolytic agent which preserves left ventricular function with a lesser rate of hemorrhagic infarction than rt-PA. Further, nasaruplase administration results in recovery of left ventricular regional wall motion and systolic function, such as Vmax.
- International Heart Journal刊行会の論文
著者
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Hayashi Kazutaka
Department Of Clinical Radiology Graduate School Of Medical Sciences Kyushu University
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Uchida Takeshi
Department Of Applied Physics Osaka City University
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Kido Hideaki
Department Of Pharmacology Central Research Labolatories The Green Cross Corporation
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Watanabe Masahiro
Department Of Agricultural Chemistry Faculty Of Agriculture The University Of Tokyo
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KIDO Hideaki
Department of Pharmacology, Product Development Laboratories, The Green Cross Corporation
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UCHIDA Takeshi
Department of Pharmacology, Product Development Laboratories, The Green Cross Corporation
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HAYASHI Kazutaka
Department of Pharmacology, Product Development Laboratories, The Green Cross Corporation
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