Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
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概要
- 論文の詳細を見る
In the smooth muscle of the rat vas deferens, 10^<-5>M cocaine shifted the dose-response curve to norepinephrine to the left and enhanced the maximal contractions to norepinephrine and methacholine. Propranolol at 10^<-4>M almost completely blocked these potentiating effects of cocaine. Sotalol or lidocaine at 10^<-4>M did not block the potentiating action of cocaine. The cocaine-induced enhancement of the methacholine contraction and its blockade by propranolol was observed in the dibenaminetreated vas deferens. Propranolol also blocked the depolarization-induced enhancement of the methacholine contraction. Together with the previous study demonstrating the calcium-antagonist action for propranolol, these results suggest that propranolol blocks the cocaine-induced enhancement by inhibiting the calcium influx through the potential-dependent calcium channel in the rat vas deferens.
- 公益社団法人日本薬学会の論文
著者
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ONO Kageyoshi
Department of Molecular Pharmacology and Pharmacotherapeutics, Graduate School of Pharmaceutical Sci
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GOMI YASUO
Department of Pharmacology, Faculty of Pharmaceutical Science, Kanazawa University
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Gomi Yasuo
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kasuya Yutaka
Department Of Pharmacology School Of Pharmacy Hoshi University
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Ono Kageyoshi
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Inagaki Osamu
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo:(pres
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Suzuki Nagao
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kanazawa University
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Suzuki Nagao
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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SUZUKI NAGAO
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University
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