Tachyphylaxis to the Inhibitory Effect of Manganese on Potassium-Induced Contractions in the Isolated Vas Deferens of the Guinea Pig
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概要
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In the isolated vas deferens of the guinea pig, the inhibitory effects of manganese (Mn^<2+>) on the contractions induced by potassium (K^+) were decreased when the contractions were induced repeatedly in the presence of Mn^<2+>. This phenomenon appeared to be tachyphylaxis to the inhibitory effects of Mn^<2+>. After the repetitive application of K^+ with Mn^<2+>, the phasic component of K^+-induced contraction was restored, while the tonic component of this contraction and resting tone were augmented by the deprivation of extracellular Mn^<2+>. When Mn^<2+> was applied during the tonic component of the K^+ -induced contraction, the phasic component of the next contraction induced by K^+ in the absence of Mn^<2+> was slightly inhibited and the tonic component of the contraction was potentiated. When extracellular calcium concentration was increased, the inhibitory effect of Mn^<2+> on K^+-induced contractions was reduced, while the tachyphylaxis to Mn^<2+> also appeared. Under this condition, the resting tone was markedly increased when the K^+-induced contraction was repeated in the presence of Mn^<2+>. In the calcium-free medium containing Mn^<2+>, although K^+ caused slow and monophasic contractions, the magnitude of the contractions was much smaller than that of the contractions induced in the normal medium containing Mn^<2+>. These results suggest that the tachyphylaxis was not produced by the decrement of the inhibitory effects of Mn^<2+> on the contractions but by the augmenting effects of intracellularly accumulated Mn^<2+> and that these augmenting effects of Mn^<2+> are not due to the direct action on the contractile proteins but due to the indirect action of Mn^<2+> which increased the availability of Ca^<2+>.
- 公益社団法人日本薬学会の論文
著者
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GOMI YASUO
Department of Pharmacology, Faculty of Pharmaceutical Science, Kanazawa University
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Gomi Yasuo
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
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Ushijima H
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kanazawa University
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USHIJIMA Hiromi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University
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