Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve.
スポンサーリンク
概要
- 論文の詳細を見る
We evaluated the effects of various intravenously administered drugs, which had been shown to influence bladder function in anesthetized and/or conscious rats, on the cystometrogram in conscious restrained-denervated rats (produced by transection of the hypogastric nerve) placed in a restraining cage in comparison to those in conscious restrained-intact rats (with the hypogastric nerve intact) placed in a restraining cage. The bladder capacity in the restraineddenervated rats was smaller than that in restrained-intact rats and did not change when they were transferred to a wide cage, but the bladder capacity of the restrainedintact rats decreased following transfer to the wide cage. Therefore, the activity of the hypogastric nerve in conscious rats appears to be stimulated by restraint. Atropine suppressed the amplitude of the micturition contraction (time to micturition in the cystometrogram). In the restrained-denervated rats, thiopental and indomethacin increased the bladder capacity at almost the same doses as those in restrained-intact rats, but it took a higher dose of morphine to increase the bladder capacity than in restrained-intact rats. These findings suggest that cystometrography in restrained-denervated rats is a useful method for evaluating the effect of a newly developed agent on bladder function without any influence from the hypogastric nerve.
- 公益社団法人 日本薬理学会の論文
著者
-
KATO Hideo
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.
-
Gomi Yasuo
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
-
MORIKAWA Kouji
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.
-
KAKIUCHI Masato
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.
-
ITO Yasuo
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.
-
Fukuoka Miki
Central Research Laboratories, Hokuriku Seiyaku Co., Ltd.
関連論文
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VII. INHIBITORY EFFECT OF DIBENAMINE ON COCAINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF GUINEA PIG
- PHYSIOLOGICAL PHARMACOKINETICS COMBINED WITH ITS PHARMACOLOGICAL EFFECT ON BLOOD FLOW RATE : AN EXAMPLE OF A NEW MUSCLE-RELAXANT, HY-770
- Effects of Mazindol on the Contractions in the Rat Vas Deferens
- Spontaneous Tone in Different Types of Longitudinal Muscle Preparations of Guinea Pig Ileum
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS.VIII.^Ca-EFFLUX FROM SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM TAENIA COLI OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. IV. ISOLATION AND ACETYLCHOLINE-CONTRACTION OF SINGLE SMOOTH MUSCLE CELLS FROM TAENIA COLI OF GUINEA-PIG
- EFFECTS OF 1-(2-CHLORO-4-HYDROXYPHENYL)-t-BUTYL-AMINOETHANOL (HOKU-81), A NEW BRONCHODILATOR, ON ISOLATED TRACHEA AND ATRIA OF GUINEA PIG
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VIII. DISSOCIATION OF INDUCTION OF SUPERSENSITIVITY FROM PRESYNAPTIC ACTION OF COCAINE ON ISOLATED VAS DEFERENS OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. VII. RESPONSE TO AGONISTS AND THE CONTRACTION VELOCITY OF TAENIA COLI OF GUINEA PIG AND THE SINGLE SMOOTH MUSCLE CELLS
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XII. INHIBITORY EFFECT OF RESERPINE ON TRIPELENNAMINE-, N, N-DIMETHYL-N', N'-DIBENZYLEHYLENEDIAMINE- AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XI. INHIBITORY EFFECT OF DIBENAMINE ON TRIPELENNAMINE-N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE- AND N, N'-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. X.EFFECT OF TRIPELENNAMINE, N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE ON THE UTILIZATION OF CALCIUM IN ACETYLCHOLINE-INDUCED CONTRACTION OF ISOLATED VAS
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. IX. NONSPECIFIC SUPERSENSITIVITY OF VAS DEFERENS OF GUINEA PIG INDUCED BY TRIPELENNAMINE, N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE
- Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
- The Uptake of Manganese Induced by Agonists in the Isolated Vas Deferens of the Guinea Pig
- Effects of Ryanodine and Nifedipine on Contractions Induced by Norepinephrine, Acetylcholine, and Potassium in the Isolated Vas Deferens of the Guinea Pig
- Tachyphylaxis to the Inhibitory Effect of Manganese on Potassium-Induced Contractions in the Isolated Vas Deferens of the Guinea Pig
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VI. EFFECT OF COCAINE ON THE UTILIZATION OF CALCIUM IN ACETYLCHOLINE-INDUCED CONTRACTION OF ISOLATED VAS DEFERENS OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. V. CALCIUM AND CAFFEINE CONTRACTION OF SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM TAENIA COLI OF GUINEA PIG
- Norepinephrine : and K^+ : Induced Mn^ : Dependent Contractions and the Dynamics of Intracellular Mn^ Changes in Dispersed Smooth Muscle Cells From Ca^ : Depleted Mn^ : Loaded Vas Deferens of the Guinea Pig
- Effects of the Functional Elimination of Sarcoplasmic Reticulum on the Manganese-Dependent Norepinephrine-Induced Contractions of the Guinea Pig Vas Deferens.
- In Vitro Pharmacological Profile of the Novel .ALPHA.1-Adrenoceptor Antagonist HSR-175.
- Role of bicarbonate ion in the postjunctional action of cocaine in the smooth muscle of the rat vas deferens.
- THE EFFECT OF DERIVATIVES OF IPTD ON BLOOD SUGAR AND GLUCAGON CONTENT OF PANCREAS
- Effects of various drugs on bladder function in conscious rats.
- Potent inhibitory activity of HSR-6071, a new antiallergic agent, on Passive Cutaneous Anaphylaxis(PCA).
- Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve.
- Stimulatory Effect of N-(4-(2-(Dimethylamino)-ethoxy)benzyl)-3,4-Dimethoxybenzamide Hydrochloride(HSR-803)on Normal and Delayed Gastrointestinal Propulsion.
- Stimulatory Effects of HSR-803 on Ileal Motor Activity.
- Tachykinin-Induced Contractions in the Circular Muscle of Guinea Pig Ileum.
- Evidence that Stretch Receptors for Peristalsis are Located in the Mucosal Layer of the Guinea Pig Ileum.