PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XII. INHIBITORY EFFECT OF RESERPINE ON TRIPELENNAMINE-, N, N-DIMETHYL-N', N'-DIBENZYLEHYLENEDIAMINE- AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
スポンサーリンク
概要
- 論文の詳細を見る
Effects of tripelennamine, N, N-dimethyl-N', N'-dibenzylethylenediamine (DBED) and N, N-dibenzyl-N', N'-dimethyl-1,2-propanediamine (DBPD) on the isotonic contractions of isolated vas deferens of intact and reserpinized guinea pigs to acetylcholine were examined. Increase in sensitivity to acetylcholine induced by tripelennamine, DBED and DBPD was attenuated remarkably by reserpine. Tripelennamine- and DBED-induced increases in Ca^<2+>-contractions were not affected by reserpine. Acetylcholine-contractions in Ca^<2+>-free Tyrode solution were inhibited by reserpine, but K^+-contractions in Ca^<2+>-free Tyrode solution were not affected by reserpine. Tripelennamine- and DBED-induced increases in acetylcholine- and K^+-contractions in Ca^<2+>-free Tyrode solution were attenuated or abolished by reserpine. DBPD decreased cholinesterase activity of vas deferens of guinea pig, but DBED did not. These results suggest that, although the Ca^<2+>-storage site utilized for acetylcholine-contraction is different from that for K^+-contraction, tripelennamine- and DBED-induced increase in Ca^<2+>-release from superficial Ca^<2+>-binding sites induced by acetylcholine and K^+ is inhibited by reserpine. It is also estimated that DBPD-induced supersensitivity to acetylcholine might be due to the inhibition of cholinesterase activity. However, the mechanism of inhibition of DBPD-induced supersensitivity by reserpine remained obscure.
- 公益社団法人日本薬学会の論文
著者
-
ARAKI KIYOSHI
Department of Pharmacology, Faculty of Pharmaceutical Science, Kanazawa University
-
GOMI YASUO
Department of Pharmacology, Faculty of Pharmaceutical Science, Kanazawa University
-
Gomi Yasuo
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
-
Araki Kiyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kanazawa University
-
Araki Kiyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
-
OHASHI TOMIJI
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University
-
Ohashi Tomiji
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kanazawa University
-
GOMI YASUO
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University
関連論文
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VII. INHIBITORY EFFECT OF DIBENAMINE ON COCAINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF GUINEA PIG
- Effects of Mazindol on the Contractions in the Rat Vas Deferens
- Spontaneous Tone in Different Types of Longitudinal Muscle Preparations of Guinea Pig Ileum
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS.VIII.^Ca-EFFLUX FROM SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM TAENIA COLI OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. IV. ISOLATION AND ACETYLCHOLINE-CONTRACTION OF SINGLE SMOOTH MUSCLE CELLS FROM TAENIA COLI OF GUINEA-PIG
- EFFECTS OF 1-(2-CHLORO-4-HYDROXYPHENYL)-t-BUTYL-AMINOETHANOL (HOKU-81), A NEW BRONCHODILATOR, ON ISOLATED TRACHEA AND ATRIA OF GUINEA PIG
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VIII. DISSOCIATION OF INDUCTION OF SUPERSENSITIVITY FROM PRESYNAPTIC ACTION OF COCAINE ON ISOLATED VAS DEFERENS OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. VII. RESPONSE TO AGONISTS AND THE CONTRACTION VELOCITY OF TAENIA COLI OF GUINEA PIG AND THE SINGLE SMOOTH MUSCLE CELLS
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XII. INHIBITORY EFFECT OF RESERPINE ON TRIPELENNAMINE-, N, N-DIMETHYL-N', N'-DIBENZYLEHYLENEDIAMINE- AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XI. INHIBITORY EFFECT OF DIBENAMINE ON TRIPELENNAMINE-N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE- AND N, N'-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. X.EFFECT OF TRIPELENNAMINE, N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE ON THE UTILIZATION OF CALCIUM IN ACETYLCHOLINE-INDUCED CONTRACTION OF ISOLATED VAS
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. IX. NONSPECIFIC SUPERSENSITIVITY OF VAS DEFERENS OF GUINEA PIG INDUCED BY TRIPELENNAMINE, N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE
- Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
- The Uptake of Manganese Induced by Agonists in the Isolated Vas Deferens of the Guinea Pig
- Effects of Ryanodine and Nifedipine on Contractions Induced by Norepinephrine, Acetylcholine, and Potassium in the Isolated Vas Deferens of the Guinea Pig
- Tachyphylaxis to the Inhibitory Effect of Manganese on Potassium-Induced Contractions in the Isolated Vas Deferens of the Guinea Pig
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VI. EFFECT OF COCAINE ON THE UTILIZATION OF CALCIUM IN ACETYLCHOLINE-INDUCED CONTRACTION OF ISOLATED VAS DEFERENS OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. V. CALCIUM AND CAFFEINE CONTRACTION OF SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM TAENIA COLI OF GUINEA PIG
- Norepinephrine : and K^+ : Induced Mn^ : Dependent Contractions and the Dynamics of Intracellular Mn^ Changes in Dispersed Smooth Muscle Cells From Ca^ : Depleted Mn^ : Loaded Vas Deferens of the Guinea Pig
- Effects of the Functional Elimination of Sarcoplasmic Reticulum on the Manganese-Dependent Norepinephrine-Induced Contractions of the Guinea Pig Vas Deferens.
- Role of bicarbonate ion in the postjunctional action of cocaine in the smooth muscle of the rat vas deferens.
- THE EFFECT OF DERIVATIVES OF IPTD ON BLOOD SUGAR AND GLUCAGON CONTENT OF PANCREAS
- Effects of various drugs on bladder function in conscious rats.
- Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve.
- Stimulatory Effects of HSR-803 on Ileal Motor Activity.
- Tachykinin-Induced Contractions in the Circular Muscle of Guinea Pig Ileum.
- Evidence that Stretch Receptors for Peristalsis are Located in the Mucosal Layer of the Guinea Pig Ileum.