PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VIII. DISSOCIATION OF INDUCTION OF SUPERSENSITIVITY FROM PRESYNAPTIC ACTION OF COCAINE ON ISOLATED VAS DEFERENS OF GUINEA PIG
スポンサーリンク
概要
- 論文の詳細を見る
Effects of cocaine on the isotonic contractions of isolated vas deferens of intact and reserpinized guinea pigs to acetylcholine were examined. Both cocaine-induced increase in sensitivity to acetylcholine and cocain-induced increase in maximum response of Ca^<2+>-contraction was attenuated remarkably by reserpine. However, cocaine-induced increase in acetylcholine- and K^+- contractions in Ca^<2+>-free Tyrode solution were not prevented by reserpine. Acetylcholine-contraction, but not K^+-contraction, in the preparation exposed for 5 min to Ca^<2+>-free Tyrode solution were inhibited by reserpine. Cocaine did not inhibit the cholinesterase activity of vas deferens of guinea pig. These results suggested that presynaptic mechanisms of cocaine-induced supersensitivity are excluded and that inhibitory effect of reserpine on cocaine-induced supersensitivity might be due to the inhibition of cocaine-induced increase in calcium-influx into smooth muscle cells of vas deferens.
- 公益社団法人日本薬学会の論文
著者
-
ARAKI KIYOSHI
Department of Pharmacology, Faculty of Pharmaceutical Science, Kanazawa University
-
GOMI YASUO
Department of Pharmacology, Faculty of Pharmaceutical Science, Kanazawa University
-
Gomi Yasuo
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
-
Araki Kiyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Kanazawa University
-
Araki Kiyoshi
Department Of Pharmacology Faculty Of Pharmaceutical Science Kanazawa University
関連論文
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VII. INHIBITORY EFFECT OF DIBENAMINE ON COCAINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF GUINEA PIG
- Effects of Mazindol on the Contractions in the Rat Vas Deferens
- Spontaneous Tone in Different Types of Longitudinal Muscle Preparations of Guinea Pig Ileum
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS.VIII.^Ca-EFFLUX FROM SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM TAENIA COLI OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. IV. ISOLATION AND ACETYLCHOLINE-CONTRACTION OF SINGLE SMOOTH MUSCLE CELLS FROM TAENIA COLI OF GUINEA-PIG
- EFFECTS OF 1-(2-CHLORO-4-HYDROXYPHENYL)-t-BUTYL-AMINOETHANOL (HOKU-81), A NEW BRONCHODILATOR, ON ISOLATED TRACHEA AND ATRIA OF GUINEA PIG
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VIII. DISSOCIATION OF INDUCTION OF SUPERSENSITIVITY FROM PRESYNAPTIC ACTION OF COCAINE ON ISOLATED VAS DEFERENS OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. VII. RESPONSE TO AGONISTS AND THE CONTRACTION VELOCITY OF TAENIA COLI OF GUINEA PIG AND THE SINGLE SMOOTH MUSCLE CELLS
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XII. INHIBITORY EFFECT OF RESERPINE ON TRIPELENNAMINE-, N, N-DIMETHYL-N', N'-DIBENZYLEHYLENEDIAMINE- AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. XI. INHIBITORY EFFECT OF DIBENAMINE ON TRIPELENNAMINE-N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE- AND N, N'-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE-INDUCED SUPERSENSITIVITY OF ISOLATED VAS DEFERENS OF G
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. X.EFFECT OF TRIPELENNAMINE, N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE ON THE UTILIZATION OF CALCIUM IN ACETYLCHOLINE-INDUCED CONTRACTION OF ISOLATED VAS
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. IX. NONSPECIFIC SUPERSENSITIVITY OF VAS DEFERENS OF GUINEA PIG INDUCED BY TRIPELENNAMINE, N, N-DIMETHYL-N', N'-DIBENZYLETHYLENEDIAMINE AND N, N-DIBENZYL-N', N'-DIMETHYL-1,2-PROPANEDIAMINE
- Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
- The Uptake of Manganese Induced by Agonists in the Isolated Vas Deferens of the Guinea Pig
- Effects of Ryanodine and Nifedipine on Contractions Induced by Norepinephrine, Acetylcholine, and Potassium in the Isolated Vas Deferens of the Guinea Pig
- Tachyphylaxis to the Inhibitory Effect of Manganese on Potassium-Induced Contractions in the Isolated Vas Deferens of the Guinea Pig
- PHARMACOLOGICAL STUDIES ON SUPERSENSITIZATION. VI. EFFECT OF COCAINE ON THE UTILIZATION OF CALCIUM IN ACETYLCHOLINE-INDUCED CONTRACTION OF ISOLATED VAS DEFERENS OF GUINEA PIG
- STUDIES ON ISOLATED SMOOTH MUSCLE CELLS. V. CALCIUM AND CAFFEINE CONTRACTION OF SINGLE SMOOTH MUSCLE CELLS ISOLATED FROM TAENIA COLI OF GUINEA PIG
- Norepinephrine : and K^+ : Induced Mn^ : Dependent Contractions and the Dynamics of Intracellular Mn^ Changes in Dispersed Smooth Muscle Cells From Ca^ : Depleted Mn^ : Loaded Vas Deferens of the Guinea Pig
- Effects of the Functional Elimination of Sarcoplasmic Reticulum on the Manganese-Dependent Norepinephrine-Induced Contractions of the Guinea Pig Vas Deferens.
- Role of bicarbonate ion in the postjunctional action of cocaine in the smooth muscle of the rat vas deferens.
- THE EFFECT OF DERIVATIVES OF IPTD ON BLOOD SUGAR AND GLUCAGON CONTENT OF PANCREAS
- Effects of various drugs on bladder function in conscious rats.
- Effects of various drugs on bladder function in conscious restrained-denervated rats placed in a restraining cage and produced by transection of the hypogastric nerve.
- Stimulatory Effects of HSR-803 on Ileal Motor Activity.
- Tachykinin-Induced Contractions in the Circular Muscle of Guinea Pig Ileum.
- Evidence that Stretch Receptors for Peristalsis are Located in the Mucosal Layer of the Guinea Pig Ileum.