Effects of Muscarinic Antagonists on Experimental Nasal Secretion in Guinea Pigs.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of muscarinic antagonists on acetylcholine (ACh)- and histamine-induced nasal secretion were investigated in guinea pigs. Inhalations of flutropium (0.01 to 0.3%) and atropine (0.03 to 0.3%) into the nasal cavities dose-dependently inhibited the nasal secretion induced by ACh. The inhibitory action of flutropium was slightly stronger than that of atropine. Inhalations of pirenzepine (0.3%) and gallamine (0.3%) had no effect on the ACh-induced nasal secretion. However, 4DAMP dose-dependently inhibited the nasal secretion induced by ACh. Inhalations of flutropium (0.3%) and diphenhydramine (0.3%) showed a similar inhibitory action on the histamine-induced nasal secretion. These results suggest that 1) inhalation into the nasal cavities of flutropium was effective in experimental model of ACh and histamine-induced nasal secretion, 2) M<SUB>3</SUB> cholinergic receptors may be dominant in the nasal secretion induced by ACh and 3) the experimental model of drug-induced nasal secretion in guinea pigs used in the present study can be employed to develop therapeutic drugs for nasal secretion.
- 公益社団法人 日本薬理学会の論文
著者
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Ohno Hiromitsu
Central Research Laboratories Ss Pharmaceutical Co. Ltd.
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Mizuno Hiroyuki
Central Research Laboratories Ss Pharmaceutical Co. Ltd.
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Iwase Nobuhisa
Central Research Laboratories Ssp Co. Ltd.
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Hosokawa Tomokazu
Department of Medicinal Plant Science, Hoshi University
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Iwase Nobuhisa
Central Research Laboratories, SS Pharmaceutical Co., Ltd.
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Kawamura Yutaka
Central Research Laboratories, SS Pharmaceutical Co., Ltd.
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