Changes in sensitivity of the rat stomach fundus to various drugs in streptozotocin-induced diabetic rats.
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概要
- 論文の詳細を見る
The changes in sensitivity of the rat stomach fundus to acetylcholine (ACh), norepinephrine (NE), isoproterenol (ISO) and to vasoactive intestinal peptide (VIP) were examined in control rats and in streptozotocin (STZ) induced diabetic rats. The dose-response curves for drugs were constructed 8 weeks after treatment with STZ. The dose-response curve for ACh in diabetic rats was shifted to the left as compared to the control curve, whereas the dose-response curves for NE, ISO and VIP were shifted to the right. These results suggest that functional changes in the autonomic nervous systems of the rat stomach fundus may occur in STZ-induced diabetic rats.
- 公益社団法人 日本薬理学会の論文
著者
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Sakamoto Akemi
Department Of Developmental Genetics (h2) Graduate School Of Medicine Chiba University
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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SAKAMOTO Akemi
Department of Pharmacology, School of Pharmacy, Hoshi University
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