Anti-inflammatory Constituents of Sappan Lignum
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概要
- 論文の詳細を見る
We performed an in vitro assay for seven compounds from methanolic extract of Sappan Lignum (CSE) that inhibit the chemical mediators of inflammation using the J774.1 cell line: brazilin (1), sappanchalcone (2), protosappanin A (3), protosappanin B (4), protosappanin C (5), protosappanin D (6), and protosappanin E (7). Those compounds were evaluated for their inhibitory effects on nitric oxide (NO) and prostaglandin E2 (PGE2) production and their suppressive effects on tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), and inducible nitric oxide synthase (iNOS) mRNA expression. As a result, we clarified that 1 inhibited NO production, and almost no inhibition in PGE2. On the contrary, 2, 6, and 7 inhibited both NO and PGE2 production and suppressed TNF-α, IL-6, COX-2, and iNOS mRNA expression. An examination of carrageenin-induced mouse paw edema suggested that the CSE contained active compounds other than 1, the main constituent in CSE. It was thus revealed that several compounds and mechanisms contributed to the anti-inflammatory effect of CSE.
- 公益社団法人 日本薬学会の論文
著者
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Sasaki Yohei
Department of Medicinal Plant Science, Hoshi University
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Nagumo Seiji
Department of Medicinal Plant Science, Hoshi University
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HOSOKAWA Tomokazu
Department of Pharmacology, School of Pharmacy, Hoshi University
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Hosokawa Tomokazu
Dep. Of Medicinal Plant Sciences Hoshi Univ.
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Hosokawa Tomokazu
Department Of Pharmacology Hoshi College Of Pharmacy
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Sasaki Yohei
Department Of Materials Science And Technology Faculty Of Science And Technology Hirosaki University
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Washiyama Makiko
Department of Medicinal Plant Science, Hoshi University
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Sasaki Yohei
Department Of Medicinal Plant Science Hoshi University
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Nagumo Seiji
Department Of Medicinal Plant Science Hoshi University
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Hosokawa Tomokazu
Department of Medicinal Plant Science, Hoshi University
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