Endothelin Type B Receptor–Induced Sustained Ca2+ Influx Involves Gq/11/Phospholipase C–Independent, p38 Mitogen-Activated Protein Kinase–Dependent Activation of Na+/H+ Exchanger

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概要

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• The mechanism for sustained Ca2+ influx activated by G protein–coupled receptors was examined. In Chinese hamster ovary cells expressing recombinant human endothelin type B receptor (ETBR) and endogenous P2Y receptor (P2Y-R), endothelin-1 elicited a sustained Ca2+ influx depending on Gq/11 protein, phospholipase C (PLC), Na+/H+ exchanger (NHE), and p38 mitogen-activated protein kinase (p38MAPK), whereas P2Y-R–induced sustained Ca2+ influx was negligible. Functional studies showed that NHE activation by ETBR was mediated via p38MAPK but not Gq/11/PLC, while that by P2Y-R involves only Gq/11/PLC/p38MAPK. These results suggest that Gq/11/PLC-independent NHE activation via p38MAPK plays an important role in ETBR- mediated sustained Ca2+ influx.

• 社団法人 日本薬理学会の論文

著者

• Miwa Soichi

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

• AOYAGI Hiroyuki

  Department of Surgery, Tsukuba Memorial Hospital

• MURAMATSU Ikunobu

  Division of Pharmacology, Department of Biochemistry and Bioinformative Sciences, School of Medicine

• Aoyagi Hiroyuki

  Department Of Surgery Institute Of Clinical Medicine University Of Tsukuba

• Nishiya Tadashi

  Department Of Pharmacology Graduate School Of Pharmaceutical Sciences Hokkaido University

• Horinouchi Takahiro

  Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences

• Horinouchi Takahiro

  北海道大学 医学研究科細胞薬理学分野

• Muramatsu Ikunobu

  Division Of Pharmacology Department Of Biochemistry And Bioinformative Sciences School Of Medicine U

• ASANO Hiroshi

  Department of Neurosurgery,Nihon Universtity School of Medicine

• Miwa Soichi

  Division Of Pharmacology Department Of Biochemistry And Bioinformative Sciences School Of Medicine U

• Higa Tsunaki

  Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan

• Nishimoto Arata

  Department of Cellular Pharmacology, Hokkaido University Graduate School of Medicine, Japan

• Asano Hiroshi

  Department Of Electrical Engineering University Of Tokyo

• Horinouchi Takahiro

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

• Nishimoto Arata

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

• Higa Tunaki

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

• Asano Hiroshi

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

• Nishiya Tadashi

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

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