Na, K-, Mg- AND HCO<SUB>3</SUB>-ADENOSINE TRIPHOSPHATASES IN THE RABBIT BRAIN CHOROID PLEXUS
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概要
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Properties of adenosine triphosphatases (ATPases) in the choroid plexus of rabbit cerebral ventricles were investigated using tissue homogenates and subcellular fractions. Na, K-ATPase or HCO<SUB>3</SUB>-ATPase activity of choroid plexus was significantly lower than that of the brain or the kidney, respectively. Among the homogenates of choroid plexus from the lateral, third and fourth ventricles, there were no differences in the activities of Na, K-, Mg- and HCO<SUB>3</SUB>-ATPases. In the choroid plexus, Na, K-ATPase activity was demonstrated to be highest in 10, 000 × g fraction, while the highest Mg- and HCO<SUB>3</SUB>-ATPase activities were observed in 8, 000 × g fraction, the so-called mitochondrial fraction. Ion requirement, pH optimum and ouabain sensitivity of Na, K-ATPase in 10, 000 × g fraction of choroid plexus were similar to findings in erythrocytes, brain and kidney. However, properties of Mg and HCO<SUB>3</SUB>-ATPases in 8, 000 × g fraction were considerably different from those found in the brain and gastric mucosa. In the choroid plexus, thiocyanate ion inhibited Mg-ATPase as well as HCO<SUB>3</SUB>-ATPase. These results indicate that characteristics of ATPase systems in the choroid plexus are to some extent different from those in tissues such as brain, kidney and gastric mucosa.
- 社団法人 日本薬理学会の論文
著者
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Miwa Soichi
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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Inagaki Chiyoko
Department Of Biology Kyoto College Of Pharmacy
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Takaori Shuji
Department Of Pharmacology Shimane Medical University
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FUJIWARA Motokazu
Department of Pharmacology, Faculty of Medicine, Kyoto University
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Miwa Soichi
Department Of Cellular Pharmacology Graduate School Of Medicine Hokkaido University
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INAGAKI Chiyoko
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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INAGAKI Chiyoko
Departmctit of Pharmacology, Faculty of Medicine, Kyoto University
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TAKAORI Shuji
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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MIWA Soichi
Departments of Neurosurgery, Faculty of Medicine, Kyoto University
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FUJIWARA Motokazu
Departments of Pharmacology, Faculty of Medicine, Kyoto University
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