Improvement of Postischemic Dopaminergic Dysfunction by Edaravone, a Free Radical Scavenger

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概要

• 論文の詳細を見る

• Effects of a free radical scavenger, edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), on ischemia/reperfusion-induced dysfunctions of rat striatal dopaminergic neurons were examined using in vivo brain microdialysis. During transient forebrain ischemia, dopamine levels in dialysates were elevated 140-fold above controls but rapidly recovered after reperfusion. The increase in dopamine levels induced by high K+ stimulation after reperfusion was far smaller than that of the controls. Pretreatment with edaravone but not post-treatment dose-dependently improved the response to high K+ but not the massive dopamine increase during ischemia. These results suggest that free radicals produced during ischemia play more important roles in ischemia/reperfusion-induced dysfunctions of dopaminergic neurons.

• 2007-05-20

著者

• Miwa Soichi

  Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine

• Miwa Soichi

  Division Of Pharmacology Department Of Biochemistry And Bioinformative Sciences School Of Medicine U

• Miwa Soichi

  Dep. Of Cellular Pharmacology Hokkaido Univ. Graduate School Of Medicine Jpn

• AKIYAMA Yoshinori

  Department of Neurosurgery, Tenri Hospital

• Akiyama Yoshinori

  Department Of Neurosurgery Tenri Hospital

• Akiyama Yoshinori

  Department Of Biology Faculty Of Science University Of Kanazawa

• Morishima Shigeru

  Division Of Pharmacology Department Of Biochemistry And Bioinformative Sciences School Of Medicine U

• Miwa Soichi

  Department Of Cellular Pharmacology Graduate School Of Medicine Hokkaido University

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