PHARMACOLOGICAL ACTIONS OF LEUKOTRIENES C_4,D_4 AND E_4 ON GUINEA PIG ISOLATED TAENIA CAECUM AS A PREPARATION TO STUDY LEUKOTRIENES
スポンサーリンク
概要
- 論文の詳細を見る
The contractile effects of leukotrienes (LTs) C_4,D_4 and E_4 were studied in guinea pig isolated taenia caecum. LTs C_4,D_4 and E_4 contracted taenia caecum at low concentrations in a concentration-dependent manner. The response to LTs was not influenced by a γ-glutamyl transpeptidase inhibitor (L-serine borate), aminopeptidase inhibitor (L-cysteine) or cyclooxygenase inhibitor (flurbiprofen), suggesting that LTC_4 and LTD_4 were not metabolized or metabolized only slightly in the guinea pig isolated taenia caecum, and that each of the LTs showed the direct contractile action. Furthermore, FPL55712 antagonized the response to LTD_4 and LTC_4 competitively but not that to LTE_4. These results suggested that the guinea pig isolated taenia caecum is useful preparation to study the pharmacological actions of LTs.
- 公益社団法人日本薬学会の論文
著者
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SATO Takahiro
Department of Macromolecular Science, Graduate School of Science, Osaka University
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Sato Takahiro
Department Of Gastroenterological Surgery Saitama International Medical Center Saitama Medical Unive
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OHASHI MITSUO
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Ohashi Mitsuo
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Sato Takahiro
Department Of Agricultural And Biological Chemistry College Of Bioresource Sciences Nihon University
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Sato Takahiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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