EFFECT OF MORPHINE ON THE STIMULI-INDUCED CALCIUM UPTAKE INTO SYNAPTOSOMES ISOLATED FROM MORPHINE-TOLERANT RATS
スポンサーリンク
概要
- 論文の詳細を見る
Effects of morphine on calcium uptake into synaptosomes isolated from acutely or chronically morphine-tolerant rat brain was studied. Addition of morphine inhibited the depolarization-stimulated uptake of calcium without affecting uptake under nondepolarizing conditions. This inhibition was prevented by simultaneous addition of naloxone with morphine before calcium uptake was initiated. Acute tolerance to morphine increased depolarization-stimulated synaptosomal calcium uptake. On the other hand, chronic exposure of rats to morphine to elicit tolerance to and physical dependence on morphine did not influence synaptosomal calcium uptake. However, these preparations apparently lost the ability of in vitro morphineinhibition of calcium uptake into the synaptosomes. Our results suggested that adaptive changes of synaptosomal calcium uptake produced by exposure to morphine may be involved in tolerance and physical dependence development, but influence of morphine on calcium uptake by the synaptosomes isolated from the rats acutely tolerance to morphine was differed from that of chronic tolerant rats.
- 社団法人 日本薬理学会の論文
著者
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Konno Fukio
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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