ALTERATIONS IN SPONTANEOUS ACTIVITY OF THE ISOLATED FROG SPINAL CORD IN CALCIUM-FREE ENVIRONMENT
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概要
- 論文の詳細を見る
Spontaneous electrical activity of the isolated frog spinal cord was examined in Ca<SUP>2+</SUP> -free environment. Spontaneous discharges from the central root altered in four distinguishable steps. The first step was an immediate increase in the rate of spontaneous discharges and the second was a gradual decrease. The third was the occurrence of rhythmical bursts, and the last, the appearance of continuous firing. The rhythmical bursts could be depressed by the addition of metabolic inhibitors (ouabain or dinitrophenol in a concentration of 5×10<SUP>-5</SUP> M) as well as of Ca<SUP>2+</SUP> -chelating agents (EDTA or EGTA in a concentration of 10<SUP>-3</SUP> M). Our results suggest that the occurrence of the rhythmical bursts requires a metabolic pumping process to redistribute Na<SUP>+</SUP> and K<SUP>+</SUP> across the membrane and a small amount of Ca<SUP>2+</SUP> for transmitter secretion.
- 社団法人 日本薬理学会の論文
著者
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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Kudo Yoshihisa
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences Nagoya City University:(prese
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KIM Kiyoe
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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KIM Kiyoe
Department of Chemical Pharmacology, Faculty of Pharmacenttical Sciences, Nagoya City University
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KUDO Yoshihisa
Department of Chemical Pharmacology, Faculty of Pharmacenttical Sciences, Nagoya City University
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