EFFECTS OF ZOPICLONE AND BENZODIAZEPINES ON SPINAL REFLEXES, ANEMIC DECEREBRATE RIGIDITY AND BENZODIAZEPINE BINDING
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概要
- 論文の詳細を見る
Whether or not zopiclone, a new sleep-inducing drug, exerted a similar effect to that of benzodiazepines was examined. The drug inhibited crossed extensor reflexes in chicks and augmented the dorsal root-dorsal root reflexes in rats without affecting the mono- and polysynaptic reflexes. The site of its action was considered to be located in the spinal cord since the effect on the dorsal root reflex was observed also in the spinal rats. Zopiclone selectively reduced the phasic responses of anemic decerebrate rigidity like benzodiazepines in rats. Despite the structural difference from the benzodiazepines, zopiclone dose-dependently inhibited [<SUP>3</SUP>H]flunitrazepam binding in rat brain membranes, although the potency was weaker. These results suggested that zopiclone exerts CNS actions via benzodiazepine receptors.
- 社団法人 日本薬理学会の論文
著者
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Goto Masayoshi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kondo Mitsuru
Department Of Chemistry Faculty Of Science Shizuoka University
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Ono Hideki
Department Of Cardiology Ninon University Surugadai Hospital
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MATSUMOTO Kinzo
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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GOTO Masayoshi
Department of Biological Science, Research and Development Laboratories, Hoechst Japan Limited
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