EFFECTS OF VALPROIC ACID ON SPINAL REFLEXES AND [^3H]MUSCIMOL AND [^3H]DIAZEPAM BINDING IN BRAIN MEMBRANES IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
It was examined whether the anticonvulsant activity of valproic acid (di-n-propylacetic acid, DPA) was exerted via the inhibitory GABA system in the central nervous systems (CNS). Dorsal root reflexes (DR-DRR) were not augmented but intensely suppressed following the administration of DPA (50 and 200mg/kg, i.v.). DPA did not depolarize the resting dorsal root potentials. These electophytsiological findings may indicate that DPA does not potentiate GABA system in the spinal cord of rats. DPA (1 and 10mM) neither affected the binding of 2 or 40nM of [^3H] muscimol nor the binding of [^3H] diazepam in the rat brain membranes ; the same concentrations of DPA did not affect the enhancement of binding of [^3H] diazepam induced by the addition of GABA (100μM). The result obtained from binding assays indicates that DPA does not interact with the GABA-benzodiazepine receptor complex. The findings in the present study do not support the proposal that the anticonvulsant action of DPA is exerted by potentiation of the GABA system in the CNS.
- 社団法人日本薬学会の論文
著者
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Goto Masayoshi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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FUKUDA Hideomi
Department of Pharmacology, College of Pharmacy, Nihon University
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Fukuda Hideomi
Department Of Pharmacology College Of Pharmacy Nihon University
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HASEBE YASUSHI
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tok
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KATO KOKI
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tok
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KANEKO TSUGIO
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tok
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Kato Koki
Department Of Radiology Akita University School Of Medicine
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Kato Koki
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kaneko Tsugio
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Hasebe Yasushi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Hasebe Yasushi
Department Of Applied Chemistry Faculty Of Engineering Saitama Institute Of Technology
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FUKUDA Hideomi
Department of Toxicology and Pharmacology, Faculty of Pharmaceutical Sciences, The University of Tokyo
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FUKUDA Hideomi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Nagoya City University
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GOTO Masayoshi
Department of Biological Science, Research and Development Laboratories, Hoechst Japan Limited
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Kato Koki
Department of Chemistry, College of Science and Engineering, Aoyama Gakuin University
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