Withdrawal Like Responses of Rat Hippocampal Slices Following Brief Exposure to Morphine.
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概要
- 論文の詳細を見る
An acutely acquired dependence was investigated in rat hippocampal slices after brief exposure to morphine. Morphine augmented the population spike amplitude. Naloxone not only reversed the augmentation but decreased the amplitude to a level below that of the control. The inhibitory effect of naloxone correlated with the period of preincubation with morphine. These results suggested that the decreased response may indicate the withdrawal state acquired in vitro.
- 公益社団法人 日本薬理学会の論文
著者
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Kusama Tadashi
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Murakami Hajime
Department of Imaging Devices Research, Hitachi, Ltd., Materials Research Laboratory, Hitachi, Ibaraki 319-1292, Japan
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Kusama Tadashi
Department of Physiology and Anatomy, Nihon University College of Pharmacy
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Murakoshi Yoshie
Department of Pharmacology, Nihon University College of Pharmacy
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- Withdrawal Like Responses of Rat Hippocampal Slices Following Brief Exposure to Morphine.