Design and Synthesis of a Novel Water-Soluble NMDA Receptor Antagonist with a 1, 4, 7, 10-Tetraazacyclododecane Group
スポンサーリンク
概要
- 論文の詳細を見る
Polyamines, especially spermine, inhibit N-methyl-D-aspartate (NMDA) receptors as open channel blockers. Two types of water-soluble NMDA receptor antagonist, ACCn (1) and TGCn (2), with a 1, 4, 7, 10-tetraazacyclododecane cyclic polyamine group, were synthesized and the effects of both compounds on NMDA receptors were studied using voltage-clamp recordings of recombinant NMDA receptors expressed in Xenopus oocytes. These compounds inhibited macroscopic currents in both NR1/NR2A and NR1/NR2B receptor subtypes in oocytes voltage-clamped at -70mV. Inhibition by the compounds of NR1/NR2A receptors were more prominent than that of NR1/NR2B receptors. The inhibitory effects of ACCn (1) on both NMDA receptors were more potent than those of TGCn (2).
- 公益社団法人日本薬学会の論文
- 2005-04-01
著者
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Kusama T
Laboratory Of Physiology And Anatomy College Of Pharmacy Nihon University
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Kusama Tadashi
School Of Pharmacy Nihon Univ.
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Kusama Tadashi
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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MASUKO Takashi
College of Pharmacy, Nihon University
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KUSAMA Tadashi
College of Pharmacy, Nihon University
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METORI Koichi
College of Pharmacy, Nihon University
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KIZAWA Yasuo
College of Pharmacy, Nihon University
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MIYAKE Muneharu
College of Pharmacy, Nihon University
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Kizawa Yasuo
School Of Pharmacy Nihon Univ.
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Kizawa Yasuo
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Metori Koichi
College Of Pharmacy Nihon University
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Miyake Muneharu
College Of Pharmacy Nihon University
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Miyake Muneharu
School Of Pharmacy Nihon Univ.
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