Evidence for the AT_1 Subtype of the Angiotensin II Receptor in the Rat Submandibular Gland
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概要
- 論文の詳細を見る
We have characterized angiotensin II (Ang II) receptor subtypes on rat submandibular gland membranes using a radioligand binding assay. [^3H]Ang II binding to the membrane fractions exhibited both high (K_d=0.08 nM, B_<max>=2.19 fmol/mg protein) and low (K_d=4.19 nM, B_<max>=13.7 fmol/mg protein) affinity. Ang II, Ang III and saralasin completely displaced the [^3H]Ang II binding, whereas CV-11974,an AT_1 receptor antagonist and PD123319,an AT_2 receptor antagonist maximally displaced up to approximately 87 and 13% of the total binding, respectively. [^3H]DuP753 binding to the membrane fractions exhibited a single population of binding site with a K_d of 4.22 nM and B_<max> of 3.77 pmol/mg protein. Ang II, Ang III and CV-11974 completely displaced the [^3H]DuP753 binding with slope factors near unity, but PD123319 did not. These findings suggest that rat submandibular gland membranes contain predominantly the AT_1 receptor subtype.
- 公益社団法人日本薬学会の論文
- 2000-10-01
著者
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三浦 進司
School of Pharmaceutical Sciences University of Shizuoka
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kizawa Yasuo
School Of Pharmacy Nihon Univ.
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Kizawa Yasuo
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Matsubara Shigeru
Department Of Physical Education Nihon University College Of Pharmacy
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Osawa M
Division Of Health & Sport Sciences Nihon University College Of Industrial Technology
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Saito K
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Sano Masakazu
Department Of Oral Physiology Showa University School Of Dentistry
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SAITO Kiyoshige
Physiology & Anatomy Nihon University College of Pharmacy
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KIZAWA Yasuo
Physiology & Anatomy Nihon University College of Pharmacy
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OSAWA Masami
Division of Health & Sport Sciences, Nihon University College of Industrial Technology
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IWAMOTO Keishi
Department of Physical Education Nihon University College of Pharmacy
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MURAKAMI Hajime
Physiology & Anatomy Nihon University College of Pharmacy
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MURAKAMI Hajime
Department of Physiology and Anatomy, Nihon University College of Pharmacy
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Iwamoto K
Eisai Co. Ltd. Gifu Jpn
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Sasaki Kanako
Riken Kanagawa Jpn
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Murakami H
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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