ESR Imaging on a Solid-tumor-bearing Mouse Using Spin-labeled Dextran
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概要
- 論文の詳細を見る
Imaging of a tumor with ESR was tried using two different types of spin probes, a low molecular weight spin probe, CPROXYL, and a polymer spin probe, TEMPO-DX. Spin probes were administered to a mouse bearing a solid tumor that was a transplanted Ehrlich's ascites carcinoma in the back, using two methods, conventional intraperitoneal injection and continuous intravenous injection with a micro-feeder. First, the accumulation of the probe was examined by X-band ESR. CPROXYL, which was administered to a mouse intraperitoneally, was exclusively retained in urine, showing that it was rapidly excreted into the bladder, while TEMPO-DX was absorbed from the peritoneal cavity with difficulty to the vessel. Using continuous intravenous injection, CPROXYL was also rapidly excreted, but it was confirmed that TEMPO-DX concentrated in tumor tissue because it has a long half-life in vivo. In addition, measurement of ESR imaging was done to measure the distribution of spin probes with continuous intravenous injection. The strongest spot of CPROXYL was observed on ESR images, showing the accumulation at the bladder, while the spot of TEMPO-DX was observed in the solid tumor of the back of the mouse. These results suggest that TEMPO-DX could stay much longer than a low molecular spin probe in vivo and concentrate at the tumor. PO-DX may be useful for developing specific ESR imaging agents for tumor.
- 社団法人日本農芸化学会の論文
- 2001-04-23
著者
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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SAITO Kieko
Institute for Environmental Sciences, University of Shizuoka
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KAZAMA Shunsuke
School of Pharmaceutical Sciences, University of Shizuoka
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TANIZAWA Hisayuki
School of Pharmaceutical Sciences, University of Shizuoka
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ITO Tomohiro
Graduate School of Engineering, Yamagata University
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TADA Mika
Graduate School of Engineering, Yamagata University
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OGATA Tateaki
Graduate School of Engineering, Yamagata University
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YOSHIOKA Hisashi
Institute for Environmental Sciences, University of Shizuoka
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Tada Mika
Graduate School Of Engineering Yamagata University
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Saito Kieko
Institute For Environmental Sciences University Of Shizuoka
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Ogata T
Yamagata Univ. Yonezawa Jpn
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Ogawa T
Kitasato Univ. Iwate Jpn
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Yoshioka H
Univ. Shizuoka Shizuoka Jpn
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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Tanizawa H
School Of Pharmaceutical Sciences University Of Shizuoka
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Kazama S
School Of Pharmaceutical Sciences University Of Shizuoka
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Kazama Shunsuke
School Of Pharmaceutical Sciences University Of Shizuoka
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Sasaki Kanako
Riken Kanagawa Jpn
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Ito Tomohiro
Graduate School Of Engineering Yamagata University
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Yoshioka Hisashi
Institute For Environmental Science University Of Shizuoka
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