Hepatic Injury-Specific Conversion of Mouse Plasma Hyaluronan Binding Protein to the Active Hetero-Dimer Form
スポンサーリンク
概要
- 論文の詳細を見る
Plasma hyaluronan binding protein(PHBP)is produced only in liver and kidney in mouse. The induction of PHBP mRNA and the conversion of pro PHBP to the active hetero-dimer form were studied after CC1_4, _D-galactosamine, HgC1_2 or turpentine administration and after partial hepatectomy. The results indicated that the administrations of CC1_4 and _D-galactosamine, which caused hepatic failure, and the partial hepatectomy enhanced the conversion of pro PHBP to the active two-chain form in the plasma. On the other hand, HgCl_2 which injured kidney and turpentine which led to inflammation were not involved in the activation of PHBP. The weak induction and suppression of PHBP mRNA were observed in the liver at 3 h and 12 h, respectively, after the CCl_4 administration. However, HgCl_2 and turpentine did not influence the amount of PHBP mRNA. These results suggested the hepatic injury-specific activation of PHBP in plsma. PHBP may act as an early factor in the cascade for the tissue remodeling in liver following hepatic injury, i.e., PHBP activates urokinase, urokinase activates matrix metalloproteinases(MMPs)and MMPs degrade extracellular matrix for liver regeneration.
- 公益社団法人日本薬学会の論文
- 2001-08-01
著者
-
Choi-miura Nam-ho
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
-
Saito Kiyomi
Department of phamacology, showa University School of Medicine
-
Saito Kiyomi
Department Of Phamacogenomics School Of Phamaceutical Sciences Showa University
-
SANO Yoshihiro
Department of Physiological Chemistry, School of Pharmaceutical Sciences Showa University
-
TOMITA Motowo
Department of Physiological Chemistry, School of Pharmaceutical Sciences Showa University
-
Takahashi Katsuhiko
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
-
Takahashi Katsuhiko
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
Choi‐miura N‐h
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
-
OTSUYAMA Kayo
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
-
冨田 昌弘
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
Tomita Motowo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Showa University
-
Saito K
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
-
Sano Y
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
Sano Yoshihiro
Department Of Forest Science Faculty Of Agriculture Hokkaido University
-
Takahashi K
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
Otsuyama Kayo
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
-
Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
-
Shinozaki Kazuo
Riken Kanagawa Jpn
-
Sano Y
Graduate School Of Agriculture Hokkaido University
-
Sasaki Kanako
Riken Kanagawa Jpn
-
Takahashi Katsuhiko
Department Of Artificial Complex Systems Engineering
-
Takahashi Katsuhiko
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
関連論文
- FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
- FRS-020 Adiponectin Transgenic Mice can Strongly Suppress Neointimal Hyperplasia after Vascular Injury without Enhanced Expression of It's Receptor in Vessels(FRS4,Topics in Peripheral Arterial Disease (H),Featured Research Session (English),The 73rd Annu
- 解説 ビオチン-アビジン架橋の細胞工学への応用
- Effect of Oral Treatment of Perilla frutescens and Its Constituents on Type-I Allergy in Mice
- OE-352 Adiponectin Transgenic Mice Prevents Neointimal Hyperplasia after Vascular Injury(Restenosis basic/clinical-1, The 71st Annual Scientific Meeting of the Japanese Circulation Society)
- Mg^ Binding and Catalytic Function of Sphingomyelinase from Bacillus cereus
- A209 核多角体病ウイルス感染増進物質の昆虫ボックスウイルス封入体中の局在(昆虫病理学・微生物的防除)
- Purification and Characterization of a Novel Glycoprotein Which Has Significant Homology to Heavy Chains of Inter-α-Trypsin Inhibitor Family from Human Plasma
- Mouse Inter-Alpha-Trypsin Inhibitor Family Heavy Chain-Related Protein is an Acute Phase Protein Induced by Inflammation
- Regulation of Gelatin-Binding Protein 28 (GBP28) Gene Expression by C/EBP
- Cloning of the cDNA for a Mouse Homologue of Human PHBP : a Novel Hyaluronan-Binding Protein
- Isolation and Characterization of the Plasma Hyaluronan-Binding Protein (PHBP) Gene (HABP2)
- Isolation and Characterization of GBP28, a Novel Gelatin-Binding Protein Purified from Human Plasma
- Molecular Cloning and Expression of Human Liver Biliverdin-IXβ Reductase
- Purification and Characterization of a Novel Hyaluronan-Binding Protein (PHBP) from Human Plasma: It Has three EGF, a Kringle and a Serine Protease Domain, Similar to Hepatocyte Growth Factor Activator
- Isolation and Characterization of the Human Inter-α-Trypsin Inhibitor Family Heavy Chain-Related Protein (IHRP) Gene (ITIHL1)
- Primary Structure of the Pig Homologue of Human IHRP: Inter-α-Trypsin Inhibitor Family Heavy Chain-Related Protein
- Purification and Characterization of the 2nd 5'-Nucleotide-forming Nuclease from Lentinus edodes
- Effects of Kangen-karyu on Coagulation System and Platelet Aggregation in Mice
- cDNA Sequencing and Expression of Rat Mast Cell Tryptase^1
- Eosinophil Peroxidase Deficiency in Humans and Mice
- Effects of Dexamethasone and Aminophylline on Survival of Jurkat and HL-60 Cells(Pharmacology)
- Regulation Mechanism of the Serine Protease Activity of Plasma Hyaluronan Binding Protein
- ラット及びヒトへの葛根湯(Ge-Gen-Tang)経口投与による尿中排泄成分について
- Urinary and Biliary Metabolites of Puerarin in Rats
- ラットへの葛根主要成分経口投与による体内動態
- Urinary and Biliary Metabolites of Daidzin and Daidzein in Rats
- SP-40, 40 Is a Component of Plasminogen Activator Inhibitor-1-Binding Protein and Stabilizes Plasminogen Activator Inhibitor-1 Activity
- Development of a novel method for characterization of cereals by spectral phenotyping
- Pharmacological Properties of Traditional Medicines. XXII. Pharmacokinetic Study of Mulberroside A and Its Metabolites in Rat
- Pharmacological Properties of Traditional Medicines (XXI) : Analysis of Plasma, Urine and Bile of Rats after Oral Administration of Water Extract of Mori Cortex
- Inhibitory Effects of Hydrolyzable Tannins form Melastoma dodecandrum LOUR. on Nitric Oxide Production by a Murine Macrophage-Like Cell Line, RAW264.7,Activated with Lipopolysaccharide and Interferon-γ
- Efficient Production of 2-Deoxyribose 5-Phosphate from Glucose and Acetaldehyde by Coupling of the Alcoholic Fermentation System of Baker's Yeast and Deoxyriboaldolase-Expressing Escherichia coli
- Microbial Production of 2-Deoxyribose 5-Phosphate from Acetaldehyde and Triosephosphate for the Synthesis of 2'-Deoxyribonucleosides(Microbiology & Fermentation Technology)
- Identificaion of a Domain Conferring Nucleotide Binding to the N-Acetyl-D-Glucosamine 2-Epimerase(Renin Binding Protein)
- Effects of Nucleotides on N-Acetyl-D-Glucosamine 2-Epimerases (Renin-Binding Proteins) : Comparative Biochemical Studies
- Serine Acetyltransferase Involved in Cysteine Biosynthesis from Spinach : Molecular Cloning, Characterization and Expression Analysis of cDNA Encoding a Plastidic Isoform
- Pharmacological Properties of Traditional Medicine (XXIX) : Effect of Hange-shashin-to and the Combinations of Its Herbal Constituents on Rat Experimental Colitis(Pharmacognosy)
- Anti-stress Effects of 3,4,5-Trimethoxycinnamic Acid, an Active Constituent of Roots of Polygala tenuifolia (Onji)(Pharmacognosy)
- Interaction between 3,4,5-trimethoxycinnamic acid and spinosin on pentobarbital-induced sleeping time in mice
- Hepatic Injury-Specific Conversion of Mouse Plasma Hyaluronan Binding Protein to the Active Hetero-Dimer Form
- Molecular Cloning of Acid-Stable Glucose Isomerase Gene from Streptomyces olivaceoviridis E-86 by a Simple Two-Step PCR Method, and Its Expression in Escherichia coli
- Proteolytic Activation and Inactivation of the Serine Protease Activity of Plasma Hyaluronan Binding Protein
- ESR Imaging on a Solid-tumor-bearing Mouse Using Spin-labeled Dextran
- Identification of Functionally Important Cysteine Residues of the Haman Renin-Binding Protein as the Enzyme N-Acetyl-D-Glucosamine 2-Epimerase 1
- Identification of the Substrates for Plasma Hyaluronan Binding Protein
- Renin Inhibits N-Acetyl-D-Glucosamine 2-Epimerase (Renin-Binding Protein)^1
- Two Concentric Protein Shell Structure with Spikes of Silkworm Bombyx mori Cytoplasmic Polyhedrosis Virus Revealed by Small-Angle Neutron Scattering Using the Contrast Variation Method
- Serological relationship between inclusion body proteins and a virus enhancing factor of an entomopoxvirus
- Expression of Inter-α-Trypsin Inhibitor Light Chain (Bikunin) in Human Pancreas
- CHLORINATED ORGANICS PRODUCED BY CHLORINATION OF NATURAL WATER
- Amino Acid Sequence and Attachment Sites of Oligosaccharide Units of Porcine Erythrocyte Glycophorin
- Detection of Malignant Thymoma in Primary Tumor and Metastatic Lesions Using ^Tc-tetrofosmin Scintigraphy
- Evidence for the AT_1 Subtype of the Angiotensin II Receptor in the Rat Submandibular Gland
- Activation of Protein Kinase C Induces Internalization of the GABA_C Receptors Expressed in Xenopus Oocytes
- MOLECULAR BIOLOGICAL STUDY ON SERINE BIOSYNTHETIC ENZYMES IN THE PHOSPHORYLATED PATHWAY FROM Arabisopsis thaliana
- Identification of Cysteine-380 as the Essential Residue for the Human N-Acetyl-D-Glucosamine 2-Epimerase (Renin Binding Protein)
- Pharmacokinetic and Pharmacodynamic Analysis of the Antihypercalcemic Effect of Incadronate Disodium in Rats
- Simultaneous Doping Analysis of Main Urinary Metabolites of Anabolic Steroids in Horse by Ion-trap Gas Chromatography-Tandem Mass Spectrometry
- Characterization and Quantification of Fluoxymesterone Metabolite in Horse Urine by Gas Chromatography/Mass Spectrometry
- Stir bar sorptive extraction with in situ derivatization and thermal desorption-gas chromatography-mass spectrometry for measurement of phenolic xenoestrogens in human urine samples
- Cloning and Characterization of cDNA for Inter-α-Trypsin Inhibitor Family Heavy Chain-Related Protein (IHRP), a Novel Human Plasma Glycoprotein
- Spatiotemporal ESR-CT Study on the Metabolism of Spin-labeled Polysaccharide in a Mouse
- Stopped-Flow and Spectrophotometric Study on Radical Scavenging by Tea Catechins and the Model Compounds
- Beta Ray-induced Scission of DNA in Tritiated Water and Protection by a Green Tea Percolate and (-)-Epigallocatechin Gallate
- Release of Nitric Oxide from a Spin Trap, N-tert-butyl-α-phenylnitrone, under Various Oxidative Conditions
- A Spin Trap, N-tert-Butyl-α-phenylnitrone Extends the Life Span of Mice
- Enhancement of Secretion of Human Procollagen I in Mouse HSP47-Expressing Insect Cells
- Formation of Recombinant Human Procollagen I Heterotrimers in a Baculovirus Expression System
- Production of Plant Non-protein Amino Acids by Recombinant Enzymes of Sequential Biosynthetic Reactions in Bacteria
- The role of p57^ on mandibular growth in mice : By means of laser microdissection for hard tissues
- Mice Lacking a CDK Inhibitor,p57^,Exhibit Skeletal Abnormalities and Growth Retardation
- OJ-319 Adiponectin Mediates the Cardioprotective Effects of Caloric Restriction via the Activation of AMP-Activated Protein Kinase(Acute myocardial infarction, basic-2 (IHD) OJ54,Oral Presentation (Japanese),The 70th Anniversary Annual Scientific Meeting
- Development of Miniaturized Hollow-fiber Assisted Liquid-phase Microextraction with in situ Acyl Derivatization Followed by GC-MS for the Determination of Benzophenones in Human Urine Samples
- Measurement of Benzophenones in Human Urine Samples by Stir Bar Sorptive Extraction and Thermal Desorption-Gas Chromatography-Mass Spectrometry
- Determination of Benzophenones in River-water Samples Using Drop-based Liquid Phase Microextraction Coupled with Gas Chromatography/Mass Spectrometry
- Analysis of glutathione and glutathione disulfide in human saliva using hydrophilic interaction chromatography with mass spectrometry
- Pharmacological Properties of Traditional Medicines 23.Searching for Active Compounds in the Blood and Bile of Rats after Oral Administrations of Extracts of Sansohnin(酸棗仁)
- Acetic acid pulping of wheat straw under atmospheric pressure
- On the Thermal Stresses of an Infinite Plate with an Infinite Row of Circular Inclusions unber the Steady State of Temperature : Case of an Infinite Plate Having an Infinite Row of Pairs of Heat Sources
- Characterization of Acid-Stable Glucose Isomerase from Streptomyces sp., and Development of Single-Step Processes for High-Fructose Corn Sweetener (HFCS) Production
- Pharmacological Properties of Traditional Medicines(26)Effects of Sansohnin-to(酸棗仁湯)on Pentobarbital Sleep in Stressed Mice
- Hollow-fiber-supported liquid phase microextraction with in situ derivatization and gas chromatography-mass spectrometry for determination of chlorophenols in human urine samples
- Determination of urinary triclosan by stir bar sorptive extraction and thermal desorption-gas chromatography-mass spectrometry
- Improvement of Moisture Sorption of Polyurethane Fiber by Blending Cellulose
- Preparation and Characterization of Alginate-blended Rayon
- Chromatographic and mass spectrometric analysis of glutathione in biological samples
- Miniaturized hollow fiber assisted liquid-phase microextraction and gas chromatography-mass spectrometry for determination of benzophenone and derivates in human urine sample
- Miniaturized hollow fiber assisted liquid-phase microextraction with in situ derivatization and gas chromatography-mass spectrometry for analysis of bisphenol A in human urine sample
- Pharmacological Properties of Galenical Preparation-12-Components of Chinese Traditional Prescription"KANZOBUSITO"(甘草附子湯)in Rat Portal Blood after Oral Administration
- Effect of Adiponectin on Cardiac Allograft Vasculopathy
- 抗原によるB細胞選択を用いた高効率モノクローナル抗体作製法
- Reentrant Line Scheduling using Weighted Fair Queuing
- A New Heuristic Method for Capacitated Lot-sizing in Multi-stage, Multi-machine Production Systems
- Highly Sensitive Reporter Gene Assay for Dioxins in Human Plasma by Using Cycloheximide as an Enhancer Substance
- Pharmacological Properties of Traditional Medicines (XXI) : Analysis of Plasma, Urine and Bile of Rats after Oral Administration of Water Extract of Mori Cortex
- Application of a novel large-volume injection method using a stomach-shaped inlet liner in capillary gas chromatographic trace analysis of dioxins in human milk and plasma
- Epigenetic Assessment of Environmental Chemicals Detected in Maternal Peripheral and Cord Blood Samples
- Disease-dependent Differently Methylated Regions (D-DMRs) of DNA are Enriched on the X Chromosome in Uterine Leiomyoma
- Quantitative Measurement of the Novel Human Plasma Protein, IHRP, by Sandwich ELISA