The role of p57^<KiP2> on mandibular growth in mice : By means of laser microdissection for hard tissues

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概要

• 論文の詳細を見る

• p57^<KiP2> is a member of the cip/kip family of negative regulators of the cell cycle and is strongly expressed in developing chondrocytes. In ^<KiP2>-deficient mice, shortening of limbs caused by delay of calcification in endochondral ossification has been confirmed as a skeletal abnormality. The role of p57^<KiP2> has been unclear in maxillofacial morphology. In this study to evaluate the involvement of p57^<KiP2> in mandibular growth during postnatal growth, we examined the expression of p57^<KiP2> in the mandibular condylar cartilage. Expression was confirmed in the proliferative and mature-cell layers; the strongest expression was in the mature-cell layer. We also examined the expression of type X collagen genes in p57^<KiP2>-deficient mice by real time PCR and found that the expression was much lower in the condylar cartilage of newborn p57^<KiP2>-deficient mice than in that of newborn wild-type mice. It is, therefore, concluded that ^<KiP2> may play an important role in mandibular growth by promoting the final differentiation of chondrocytes in the mandibular condylar cartilage.

• 日本矯正歯科学会の論文

著者

• NAKAYAMA Keiko

  Department of Pediatrics, Wakayama Medical University, School of Medicine

• TACHIKAWA Tetsuhiko

  Department of Operative Dentistry, Showa University School of Dentistry

• MAKI Koutaro

  Department of Orthodontics, Showa University School of Dentistry

• Maki K

  Department Of Orthodontics School Of Dentistry Showa University

• Maki Koutaro

  Department Of Dentistry Showa University

• Maki Koutaro

  Department Of Orthodontics Showa University School Of Dentistry

• Nakayama Keiko

  Department Of Cardiovascular Science And Medicine Chiba University Graduate School Of Medicine

• Nakayama Kei-ichi

  Department Of Molecular And Cellular Biology Medical Institute Of Bioregulation Kyushu University:de

• Nakayama Kei-ichi

  Department Of Molecular And Cellular Biology Laboratory Of Embryonic And Genetic Engineering Medical

• Takahashi Katsuhiko

  Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University

• IRIE Tarou

  Department of Oral Pathology, School of Dentistry, Showa University

• NAKANO Haruhisa

  Department of Orthodontics, Showa University School of Dentistry

• Takahashi Katsuhiko

  Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University

• Tachikawa Tetsuhiko

  Department Of Basic Pathology Showa University

• Irie Tarou

  Department Of Basic Pathology Showa University

• WATAHIKI Junichi

  Department of Orthodontics, School of Dentistry, Showa University

• YAMAGUCHI Tetsutaro

  Department of Orthodontics, School of Dentistry, Showa University

• YAGASAKI Yoshimi

  Department of Orthodontics, School of Dentistry, Showa University

• Irie Tarou

  Department Of Oral Pathology And Diagnosis Showa University School Of Dentistry

• Nakano H

  Department Of Orthodontics School Of Dentistry Showa University

• Yamaguchi Tetsutaro

  Department Of Orthodontics Showa University School Of Dentistry

• Watahiki Junichi

  Department Of Orthodontics School Of Dentistry Showa University

• Yagasaki Yoshimi

  Department Of Orthodontics School Of Dentistry Showa University

• Takahashi Katsuhiko

  Department Of Artificial Complex Systems Engineering

• Takahashi Katsuhiko

  Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology

• NAKANO Haruhisa

  Department of Fusion Science, The Graduate University for Advanced Studies

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