Identification of the Substrates for Plasma Hyaluronan Binding Protein
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概要
- 論文の詳細を見る
Plasma hyaluronan biding protein (PHBP) is a novel serine protease, which has an amino acid sequence homology to that of hepatocyte growth factor activator (HGFA), and has a similar domain structure to that of urinary plasminogen activator (u-PA), found in human plasma. We searched the PHBP substrate in human plasma by measuring the digested protein bands on sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDSPAGE). The results showed that fibrinogen and fibronectin were the major substrates of PHBP. PHBP cleaved the α-chain at multiple sites and the β-chain between lysine^<53> but not the γ-chain of fibrinogen. Therefore, PHBP did not initiate the formation of the fibrin clot and did not cause the fibrinolysis directly. PHBP did not cleave (activate) prothrombin and plasminogen, but it converted the inactive single chain urinary plasminogen activator to the active two chain form.
- 公益社団法人日本薬学会の論文
- 2001-02-01
著者
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Choi-miura Nam-ho
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Saito Kiyomi
Department of phamacology, showa University School of Medicine
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Saito Kiyomi
Department Of Phamacogenomics School Of Phamaceutical Sciences Showa University
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TOMITA Motowo
Department of Physiological Chemistry, School of Pharmaceutical Sciences Showa University
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Takahashi Katsuhiko
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
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YODA Madoka
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
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Takahashi Katsuhiko
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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Choi‐miura N‐h
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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CHOI-MMIURA Nam-Ho
Department of Physiological Chemistry, School of Pharmaceutical Sciences, Showa University
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冨田 昌弘
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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Tomita Motowo
Department Of Hygienic Chemistry School Of Pharmaceutical Sciences Showa University
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Saito K
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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Takahashi K
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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Yoda Madoka
Department Of Physiological Chemistry School Of Pharmaceutical Sciences Showa University
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Sasaki Kanako
Riken Kanagawa Jpn
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Takahashi Katsuhiko
Department Of Artificial Complex Systems Engineering
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Takahashi Katsuhiko
Department of Applied Chemistry for Resources, Tokyo University of Agriculture and Technology
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