A Spin Trap, N-tert-Butyl-α-phenylnitrone Extends the Life Span of Mice
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概要
- 論文の詳細を見る
To charactreize the pharmacological effects of N-tertbytyl-α-phenylnirone (PBN) on life span, we administered PBN in drinking water to 24.5-month-old mice, and the survivors were counted, Their water consumption and body weights were measured as biological markers. PBN-treated animals as compared with control animals had prolonged mean and maximum life spans. Their water consumption decreased but no significant change was found in their body weights, indicating that the metabolism was improved. Results showed that PBN indeed affects physiological functions and extends life span. We propose that nitricoxide release from PBN may be involved in altering the aging process.
- 社団法人日本農芸化学会の論文
- 1998-04-23
著者
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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YOSHIOKA Hisashi
Institute for Environmental Sciences, University of Shizuoka
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Yoshioka H
Univ. Shizuoka Shizuoka Jpn
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SAITO Kieko
Gerontology Research Center, National Institute on Aging, NIH
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CUTLER Richard
Gerontology Research Center, National Institute on Aging, NIH, University of Shizuoka
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Richard G
Gerontology Research Center National Institute On Aging:(present Address) Genox Corp.
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Yoshioka Hisashi
Institute For Environmental Science University Of Shizuoka
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