Pharmacological Properties of Traditional Medicine (XXIX) : Effect of Hange-shashin-to and the Combinations of Its Herbal Constituents on Rat Experimental Colitis(Pharmacognosy)
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概要
- 論文の詳細を見る
Hange-shashin-to (HST) has been used as an herbal formula to treat inflammatory ulcerative gut diseases complicated with psychoneurosis in Japanese traditional Kampo medicine. The aim of the present study is to clarify anti-colitic effect of HST using a model of colitis induced by intracolonic instillation of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS) in rats, and to evaluate the pharmaceutical properties of its herbal components. The colonic damage was elucidated by macroscopic damage scores, colon wet weight and area of mucosal necrosis. Orally administered HST significantly reduced the colonic damage. Other rats were orally treated with singlecomponent berberine (BE), baicalin (BA), glycyrrhizin (GL) or saponin fraction of ginsenosides (GS), or with the mixture (TL) of BA, BE, GL and GS, or with the combinations of BA plus BE (BA-BE), or that of GL plus GS (GL-GS). Oral treatment of TL ameliorated colitis observations. However, no effects were found in the treatment of single-component BA, BE, GL or GS, whereas the GL-GS combination ameliorated the colitis. These results suggest that HST might suppress inflammatory bowel disease (IBD) and imply that there will be a potential benefit in the traditionally derived herbal combination.
- 公益社団法人日本薬学会の論文
- 2004-10-01
著者
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斉藤 謙一
北海道薬科大学
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Saito K
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Kano Y
Hokkaido Coll. Pharmacy Otaru Jpn
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Katagiri Yoshihlro
Hokkaido Institute Of Pharmaceutical Sciences
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Kano Yoshihiro
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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MAKINO Toshiaki
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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SAITO Ken-ichi
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Katagiri Y
Hokkaido Institute Of Pharmaceutical Sciences
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KAWASHIMA Keiko
Department of Kampo Medicinal Science, Hokkaido Pharmacutical University
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斉藤 謙一
Department Of Physiology And Anatomy Nihon University College Of Pharmacy
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NOMURA Asano
Department of Kampo Medicinal Science, Hokkaido College of Pharmacy
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Nomura Asano
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Makino T
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Saguchi Ken-ichi
Laboratory Of Biopharmaceutics School Of Pharmaceutical Sciences Showa University
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Makino Toshiaki
R&d Division Sunstar Inc.
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Makino T
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sci. Nagoya City Univ.
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Makino Toshiaki
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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川嶋 恵子
Department Of Kampo Medicinal Science Hokkaido Pharmacutical University
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Shinozaki Kazuo
Riken Kanagawa Jpn
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Sasaki Kanako
Riken Kanagawa Jpn
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Nomura A
Department Of Kampo Medicinal Science Hokkaido College Of Pharmacy
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Makino Toshiaki
Department Of Chemistry Faculty Of Science Okayam University Of Science
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Makino Taketoshi
R&d Center Sunstar Inc.
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Makino Toshiaki
Dep. Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Nagoya City Univ.
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Saito Ken-ichi
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Sakoda K
Department Of Analytical Chemistry Faculty Of Pharmaceutical Sciences Hoshi University
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Kano Yoshihiro
Department Of Gastroenterological Surgery Osaka University Graduate School Of Medicine
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